1-苄基-6-氧代-1,6-二氢-3-吡啶羧酸合成路线 （共 8 条）
反应条件
1: 2-hydroxy 5-pyridine carboxylic acid With potassium hydroxide in methanol 0.0833333 h; Heating / reflux; 2: benzyl bromide in methanol 1.5 h; Heating / reflux;
参考文献
ENCYSIVE PHARMACEUTICALS, INC.
Patent: WO2008/79371 A1, 2008 ;
Location in patent: Page/Page column 110 ;
WO 2008/079371 A1
参考文献
Anderson; Berkelhammer
Journal of the American Chemical Society, 1958 , vol. 80, p. 992,997
反应条件
potassium hydroxide 4 h; Heating;
参考文献
Buurman; Van der Plas
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 4 p. 1015 - 1018
反应条件
1: water; ethanol; sulfuric acid 2: NaIO View Scheme
参考文献
Anderson; Berkelhammer
Journal of the American Chemical Society, 1958 , vol. 80, p. 992,997
反应条件
methanol Behandeln des Reaktionsprodukts mit K3<Fe(CN)6> und wss. KOH;
参考文献
Anderson; Berkelhammer
Journal of the American Chemical Society, 1958 , vol. 80, p. 992,997
反应条件
methanol Erwaermen des Reaktionsgemisches mit wss. NaOH;
参考文献
Wiley et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 625
反应条件
1: 80 percent / potassium permanganate, NH3(l) / 4 h / -33 °C 2: 75 percent / aq. KOH / 4 h / Heating View Scheme
参考文献
Buurman; Van der Plas
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 4 p. 1015 - 1018
反应条件
Behandeln des Reaktionsprodukts mit K3<Fe(CN)6> und wss. NaOH;
参考文献
Sugasawa et al.
Yakugaku Zasshi, 1952 , vol. 72, p. 192
Chem.Abstr., 1953 , p. 6418
