3-氨基-5-溴-2-硝基吡啶合成路线 (共 4 条)
反应条件
water; potassium hydroxide in tetrahydrofuran
T=90°C;
参考文献
van Duzer, John H.; Mazitschek, Ralph
Patent: US2014/128391 A1, 2014 ;
Location in patent: Paragraph 0226; 0231; 0232 ;
反应条件
1: With pyridine; chloroformic acid ethyl ester
2: With sulfuric acid; nitric acid
T=30°C; 20 h;
3: With potassium hydroxide in ethanol; water
参考文献
AVEXA LIMITED; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (SIOC); RHODES, David, Ian; DEADMAN, John, Joseph; LE, Giang, Thanh; VAN DE GRAFF, Nicholas, Andrew; LONG, Lu; XINMING, Li; XIAO, Feng; CHANGJIANG, Yu
Patent: WO2012/6680 A1, 2012 ;
Location in patent: Page/Page column 76 ;
反应条件
1: 54 percent / H2SO4; aq. HNO3 / 0 - 20 °C
2: aq. KOH / ethanol / 1 h / 90 °C
View Scheme
参考文献
Hasegawa, Masaichi; Nishigaki, Naohiko; Washio, Yoshiaki; Kano, Kazuya; Harris, Philip A.; Sato, Hideyuki; Mori, Ichiro; West, Rob I.; Shibahara, Megumi; Toyoda, Hiroko; Wang, Liping; Nolte, Robert T.; Veal, James M.; Cheung, Mui
Journal of Medicinal Chemistry, 2007 , vol. 50, # 18 p. 4453 - 4470
反应条件
1: triethylamine; diphenyl phosphoryl azide / |Reflux
2: sulfuric acid; nitric acid / 0 - 20 °C
3: potassium hydroxide; water / tetrahydrofuran / 90 °C
View Scheme
参考文献
van Duzer, John H.; Mazitschek, Ralph
Patent: US2014/128391 A1, 2014 ;