1-对茴香基-1-苯基乙烯合成路线 （共 99 条）
反应条件
potassium phosphate; [Rh(μ-OAc)(COD)]2; diisopropylamine; cyclooctadiene in toluene
T=100°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Yu, Jung-Yi; Shimizu, Ryosuke; Kuwano, Ryoichi
Angewandte Chemie - International Edition, 2010 , vol. 49, # 36 p. 6396 - 6399
反应条件
toluene-4-sulfonic acid in toluene
3 h; Heating;
参考文献
Van Walree, Cornelis A.; Kaats-Richters, Veronica E. M.; Veen, Sandra J.; Wieczorek, Birgit; Van Der Wiel, Johanna H.; Van Der Wiel, Bas C.
European Journal of Organic Chemistry, 2004 , # 14 p. 3046 - 3056
反应条件
tetrakis(triphenylphosphine) palladium(0); oxygen; copper(l) chloride; lithium tert-butylate in 1,4-dioxane
T=70°C; 3 h;
参考文献
Zhao, Xia; Jing, Jing; Lu, Kui; Zhang, Yan; Wang, Jianbo
Chemical Communications, 2010 , vol. 46, # 10 p. 1724 - 1726
反应条件
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 2.17 h / 20 °C / |Inert atmosphere
1.2: 20 °C / |Inert atmosphere
2.1: hydrogenchloride / dichloromethane; water / 65 h / |Inert atmosphere
View Scheme
参考文献
Bess, Elizabeth N.; Sigman, Matthew S.
Organic Letters, 2013 , vol. 15, # 3 p. 646 - 649
反应条件
in diethyl ether
5 h; -20 deg C to r.t.;
参考文献
Dimitrov; Stanchev; Milenkov; Nikiforov; Demirev
Synthesis, 1991 , # 3 p. 228 - 232
反应条件
1.1: Mg / diethyl ether
1.2: 93 percent / diethyl ether / 2 h / Heating
2.1: 53 percent / p-toluenesulfonic acid / toluene / 3 h / Heating
View Scheme
参考文献
Van Walree, Cornelis A.; Kaats-Richters, Veronica E. M.; Veen, Sandra J.; Wieczorek, Birgit; Van Der Wiel, Johanna H.; Van Der Wiel, Bas C.
European Journal of Organic Chemistry, 2004 , # 14 p. 3046 - 3056
反应条件
1.1: Mg / diethyl ether
1.2: 93 percent / diethyl ether / 2 h / Heating
2.1: 53 percent / p-toluenesulfonic acid / toluene / 3 h / Heating
View Scheme
参考文献
Van Walree, Cornelis A.; Kaats-Richters, Veronica E. M.; Veen, Sandra J.; Wieczorek, Birgit; Van Der Wiel, Johanna H.; Van Der Wiel, Bas C.
European Journal of Organic Chemistry, 2004 , # 14 p. 3046 - 3056
反应条件
{C6H3[NHP(piperidinyl)2]2Pd(Cl)}; potassium carbonate in N,N-dimethyl-formamide; toluene
T=140°C; Heck reaction; 2.5 h; Inert atmosphere;
参考文献
Bolliger, Jeanne L.; Blacque, Olivier; Frech, Christian M.
Chemistry - A European Journal, 2008 , vol. 14, # 26 p. 7969 - 7977
反应条件
1: tetrahydrofuran / 2 h / 15 - 20 °C / Inert atmosphere
2: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
3: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
4: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
5: triethylamine / dichloromethane / 0 - 20 °C
6: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
反应条件
Najera palladacycle I; tetra(n-butyl)ammonium hydroxide; potassium carbonate; [HP(t-Bu)3]BF4 in N,N-dimethyl-formamide
T=130°C; Suzuki-Miyaura alkenylation; 0.333333 h; Microwave irradiation; regioselective reaction;
参考文献
Civicos, Jose F.; Alonso, Diego A.; Najera, Carmen
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 10 p. 1683 - 1687
