2-环己基-2-羟基苯乙酸合成路线 （共 28 条）
反应条件
1: platinum; acetic acid / Hydrogenation 2: Raney nickel / 150 °C / Hydrogenation View Scheme
参考文献
Smith et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 3772,3773
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
1: With 4-methyl-morpholine; benzotriazol-1-ol in dichloromethane T=0°C; 1 h; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0 - 20°C; 16 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/247628 A1, 2009 ;
Location in patent: Page/Page column 53-54 ;
US 20090247628 A1
反应条件
1: potassium carbonate; ethyl acetate View Scheme
参考文献
Adlerova,E. et al.
Collection of Czechoslovak Chemical Communications, 1964 , vol. 29, p. 97 - 120
反应条件
1: isopropyl alcohol
2: methanol
View Scheme
参考文献
Smith et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1301,1305
反应条件
acetic acid; platinum
Hydrogenation;
参考文献
CIBA
Patent: US2265185 , 1939 ;
Full Text Show Details
Smith et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 3772,3773
Full Text Show Details
CIBA
Patent: US2265184 , 1939 ;
反应条件
orthophosphorus acid; methanesulfonic acid; sodium iodide in water
T=95°C; 48 h; Inert atmosphere;
参考文献
Milne, Jacqueline E.; Storz, Thomas; Colyer, John T.; Thiel, Oliver R.; Dilmeghani Seran, Mina; Larsen, Robert D.; Murry, Jerry A.
Journal of Organic Chemistry, 2011 , vol. 76, # 22 p. 9519 - 9524
