1-环己烯-1,2-二甲酸二甲酯合成路线 （共 17 条）
反应条件
1.1: diethyl ether / 0 °C / |Inert atmosphere
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.23 h / -78 °C / |Inert atmosphere
2.2: -78 °C
View Scheme
参考文献
Malihi, Farzad; Clive, Derrick L. J.; Chang, Che-Chien; Minaruzzaman
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 996 - 1013
反应条件
1: 35 percent Chromat. / tetrahydrofuran; hexamethylphosphoric acid triamide / 10 °C
2: 92 percent / gas / 650 °C
View Scheme
参考文献
Girard, C.; Bloch, R.
Tetrahedron Letters, 1982 , vol. 23, # 36 p. 3683 - 3686
反应条件
hydrogenchloride; lithium cyclohexylisopropyl amide; iodine
1.) THF, -78 deg C, 10 min, 3.) MeOH, reflux, overnight; Multistep reaction;
参考文献
Wilkening, David; Mundy, Bradford P.
Synthetic Communications, 1984 , vol. 14, # 3 p. 227 - 238
参考文献
Wilkening, David; Mundy, Bradford P.
Synthetic Communications, 1984 , vol. 14, # 3 p. 227 - 238
参考文献
Wilkening, David; Mundy, Bradford P.
Synthetic Communications, 1984 , vol. 14, # 3 p. 227 - 238
反应条件
lithium cyclohexylisopropyl amide; iodine
1.) THF, -78 deg C, 10 min; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Wilkening, David; Mundy, Bradford P.
Synthetic Communications, 1984 , vol. 14, # 3 p. 227 - 238
反应条件
1: 1.) (i-C4H9)AlH / THF
2: 96 percent / NH3 / methanol
3: 66 percent / MnO2 / CH2Cl2
View Scheme
参考文献
Butina, Darko; Sondheimer, Franz
Synthesis, 1980 , # 7 p. 543 - 545
