反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 85 percent / BF3*Et2O / tetrahydrofuran; hexane / 1 h / -78 °C
2.1: H2 / Lindlar's catalyst / ethyl acetate / 3 h / 20 °C / atmospheric pressure
3.1: 100 mg / Mo(CO)6 / acetonitrile; H2O / 6 h / Heating
4.1: CuBr*Me2S / tetrahydrofuran; diethyl ether / 0.5 h / -78 °C
4.2: 90 percent / TMSCl; DMPU / tetrahydrofuran; diethyl ether / 1 h / -78 - -20 °C
5.1: TFA / CH2Cl2 / 2 h / 20 °C
6.1: 0.5 h / 20 °C
7.1: ceric ammonium nitrate / acetonitrile; H2O / 1 h / 20 °C
8.1: 309 mg / Et3N / DMAP / acetonitrile / 20 °C
9.1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C
10.1: pTsOH*H2O / 20 °C
11.1: 64 percent / BF3*Et2O / CH2Cl2 / 3 h / -78 - -50 °C
12.1: 70 percent / aq. HCl; AcOH / 3 h / 20 °C
View Scheme
参考文献
Hanessian, Stephen; Bayrakdarian, Malken; Luo, Xuehong
Journal of the American Chemical Society, 2002 , vol. 124, # 17 p. 4716 - 4721
