2,2,2-三氟苯乙酮合成路线 （共 295 条）
反应条件
1: 2,2,2-Trifluoro-1-phenyl-ethanone With N-methyl-2-(methylamino)ethylamine in hexane T=20°C; 0.166667 h; Inert atmosphere; 2: With diethylzinc in hexane T=20°C; 0.166667 h; Inert atmosphere; 3: acetone in hexane T=20°C; 20 h; Inert atmosphere;
参考文献
Sasaki, Shigeru; Kikuchi, Kasumi; Yamauchi, Takayasu; Higashiyama, Kimio
Synlett, 2011 , # 10 art. no. U02211ST, p. 1431 - 1434
反应条件
lithium hydride in pentane 1 h; Heating;
参考文献
Sosnovskikh, V. Ya.; Ovsyannikov, I. S.; Aleksandrova, I. A.
Journal of Organic Chemistry USSR (English Translation), 1992 , vol. 28, # 3.1 p. 420 - 426
Zhurnal Organicheskoi Khimii, 1992 , vol. 28, # 3 p. 518 - 526
反应条件
iso-PrOLi in toluene T=20 - 80°C; 6 h;
参考文献
Sokeirik, Yasser S.; Sato, Kazuyuki; Omote, Masaaki; Ando, Akira; Kumadaki, Itsumaro
Journal of Fluorine Chemistry, 2006 , vol. 127, # 1 p. 150 - 152
反应条件
1: 92 percent / diethyl ether / 1 h / 20 °C 2: 56 percent / aq. HCl / ethanol / 1 h / Heating View Scheme
参考文献
Barten, Jan Alexander; Funabiki, Kazumasa; Roeschenthaler, Gerd-Volker
Journal of Fluorine Chemistry, 2002 , vol. 113, # 1 p. 105 - 109
反应条件
sodium hydride 1) DMF, H2O, 60 deg C, 30 min, 2) DMF, 80 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Delgado, Antonio; Clardy, Jon
Tetrahedron Letters, 1992 , vol. 33, # 20 p. 2789 - 2790
反应条件
potassium fluoride; 18-crown-6 ether in N,N-dimethyl-formamide T=110°C; 5 h;
参考文献
Nader, Bassam S.; Cordova, Jody A.; Reese, Karen E.; Powell, Cynthia L.
Journal of Organic Chemistry, 1994 , vol. 59, # 10 p. 2898 - 2901
反应条件
n-butyllithium in tetrahydrofuran T=0 - 25°C;
参考文献
Bennani; Vanhessche; Sharpless
Tetrahedron Asymmetry, 1994 , vol. 5, # 8 p. 1473 - 1476
反应条件
triphenylphosphine; isopropyl alcohol; Wilkinson's catalyst in tetrahydrofuran T=25°C; 3 h;
参考文献
Lebel, Helene; Paquet, Valerie
Organic letters, 2002 , vol. 4, # 10 p. 1671 - 1674
反应条件
in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Pine, Stanley H.; Pettit, Robert J.; Geib, Gregory D.; Cruz, Susana G.; Gallego, Claudio H.; et al.
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1212 - 1216
反应条件
1: triphenyl-methyl-phosphonium iodide With potassium tert-butylate in tetrahydrofuran; tert-butyl alcohol T=-78°C; 0.25 h; 2: 2,2,2-Trifluoro-1-phenyl-ethanone in tetrahydrofuran; tert-butyl alcohol T=-78 - 20°C; Wittig reaction;
参考文献
Van Alem, Kaj; Belder, Geerte; Lodder, Gerrit; Zuilhof, Han
Journal of Organic Chemistry, 2005 , vol. 70, # 1 p. 179 - 190
