2,2,2-三氟苯乙酮合成路线 （共 295 条）
反应条件
1: NaBH4, NaOH / methanol / 1 h / 25 °C 2: 1.) NaH / 1) ether, 1 h; 2) ether, 4 h View Scheme
参考文献
DePuy,C.H.; Schultz,A.L.
Journal of Organic Chemistry, 1974 , vol. 39, # 7 p. 878 - 881
反应条件
triethylamine in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 80°C; 3.25 h;
参考文献
Bizet, Vincent; Pannecoucke, Xavier; Renaud, Jean-Luc; Cahard, Dominique
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 56 - 61
反应条件
triethylamine in tetrahydrofuran; N,N-dimethyl-formamide T=80°C; Horner-Wadsworth-Emmons reaction; 2 h;
参考文献
Konno, Tsutomu; Takehana, Tsuyoshi; Mishima, Makoto; Ishihara, Takashi
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3545 - 3550
反应条件
Fe(TCP)Cl; polyethylene supported arsine; polymethylhydrosiloxane in toluene T=110°C; Wittig type reaction; 38 h; Inert atmosphere; optical yield given as percent de;
参考文献
Wang, Peng; Liu, Chun-Rong; Sun, Xiu-Li; Chen, Shuai-Shuai; Li, Jun-Fang; Xie, Zuowei; Tang, Yong
Chemical Communications, 2012 , vol. 48, # 2 p. 290 - 292
反应条件
1: 1-bromopinacolone With triethylamine; triphenylphosphine in tetrahydrofuran 2 h; Reflux; 2: 2,2,2-Trifluoro-1-phenyl-ethanone in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 120 h; Reflux;
参考文献
Bizet, Vincent; Pannecoucke, Xavier; Renaud, Jean-Luc; Cahard, Dominique
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 56 - 61
反应条件
triethylamine in tetrahydrofuran; N,N-dimethyl-formamide T=80°C; Horner-Wadsworth-Emmons reaction; 2 h;
参考文献
Konno, Tsutomu; Takehana, Tsuyoshi; Mishima, Makoto; Ishihara, Takashi
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3545 - 3550
反应条件
1: 82 percent / acetic acid / ethanol / 8 h / Heating 2: 40 percent / KOH / methanol / 1 h / Heating View Scheme
参考文献
Shi, Guoqiang; Xu, Yuanyao
Journal of Fluorine Chemistry, 1990 , vol. 46, # 1 p. 173 - 178
反应条件
oxygen; iron(III) chloride; nitrogen(IV) oxide; ozone in dichloromethane T=-10 - 0°C; 1 h; Yields of byproduct given;
参考文献
Suzuki; Tatsumi; Maeda
Synthesis, 1995 , # 11 p. 1353 - 1354
参考文献
Smissman,E.E. et al.
Journal of Organic Chemistry, 1968 , vol. 33, p. 4231 - 4236
反应条件
1: 94 percent / NH2OH*HCl, NaOAc / H2O; ethanol / 10 h / 75 °C 2: 70 percent / H2, AcOH / 10percent Pd/C / diethyl ether / 20 - 25 °C / 2068.6 - 2327.2 Torr View Scheme
参考文献
SENEXIS LIMITED; BTG INTERNATIONAL LIMITED; SCOPES, David
Patent: WO2011/42496 A1, 2011 ;
WO 2011/042496 A1
