2,2,2-三氟苯乙酮合成路线 （共 295 条）
反应条件
hydrazine hydrate in diethylene glycol
参考文献
Okano,T.; Ito,K.; Ueda,T.
Journal of Fluorine Chemistry, 1986 , vol. 32, p. 377
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 2 h / 0 - 20 °C
2.1: diisobutylaluminium hydride / dichloromethane / 2 h / 0 °C
View Scheme
参考文献
Bizet, Vincent; Pannecoucke, Xavier; Renaud, Jean-Luc; Cahard, Dominique
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 56 - 61
反应条件
in acetonitrile
T=30°C; Irradiationother ketone as acceptor, other cymene isomers, selectivity for attack at primary vs tertiary position of the cymenes, relative chemical quantum yield; Product distributionMechanism;
参考文献
Albini, A.; Sulpizio, A.
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2147 - 2152
反应条件
in acetonitrile
T=30°C; Irradiationother ketone as acceptor, other cymene isomers, selectivity for attack at primary vs tertiary position of the cymenes, relative chemical quantum yield; Product distributionMechanism;
参考文献
Albini, A.; Sulpizio, A.
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2147 - 2152
反应条件
hydroxide
reaction enthalpies; Product distributionThermodynamic data;
参考文献
Staneke, Paul O.; Ingemann, Steen; Nibbering, Nico M. M.
Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 3 p. 179 - 184
反应条件
T=20°C; 0.5 h; Reagent/catalystSolventTimeTemperature;
参考文献
Serizawa, Hiroki; Aikawa, Kohsuke; Mikami, Koichi
Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17692 - 17697
参考文献
Illa, Ona; Bagan, Xavier; Cazorla, Anna M.; Lyon, Celine; Baceiredo, Antoine; Branchadell, Vicenc; Ortuno, Rosa M.
Journal of Organic Chemistry, 2006 , vol. 71, # 14 p. 5320 - 5327
反应条件
1: 86 percent / diethyl ether / 2 h / -50 °C
2: 70 percent / 0.1 Torr / Heating
View Scheme
参考文献
Saalfrank, Rolf W.; Paul, Winfried; Schierling, Peter; Schueler, Heide; Wilhelm, Eberhard
Chemische Berichte, 1982 , vol. 115, # 1 p. 57 - 64
反应条件
magnesium in tetrahydrofuran
T=0°C; 2 h;
参考文献
University of Southern California
Patent: US6872855 B1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
phenyl-magnesium bromide in tetrahydrofuran; diethyl ether
T=65°C; Tishchenko reaction; 4 h; Inert atmosphere;
参考文献
Cronin, Linda; Manoni, Francesco; O'Connor, Cornelius J.; Connon, Stephen J.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 17 p. 3045 - 3048
