2,2,2-三氟苯乙酮合成路线 （共 295 条）
反应条件
in acetonitrile
T=30°C; Irradiation; Further byproducts given;
参考文献
Albini, A.; Sulpizio, A.
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2147 - 2152
反应条件
in acetonitrile
T=30°C; Irradiationother ketone as acceptor, other cymene isomers, selectivity for attack at primary vs tertiary position of the cymenes, relative chemical quantum yield; Product distributionMechanism;
参考文献
Albini, A.; Sulpizio, A.
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2147 - 2152
参考文献
Kray,W.D.; Rosser,R.W.
Journal of Organic Chemistry, 1977 , vol. 42, # 7 p. 1186 - 1189
反应条件
2: (i) aq. HCl, NaNO2, (ii) /BRN= 3587243/, CuCl
View Scheme
参考文献
Kray,W.D.; Rosser,R.W.
Journal of Organic Chemistry, 1977 , vol. 42, # 7 p. 1186 - 1189
反应条件
trifluorormethanesulfonic acid
参考文献
Kray,W.D.; Rosser,R.W.
Journal of Organic Chemistry, 1977 , vol. 42, # 7 p. 1186 - 1189
反应条件
1: sodium tetrahydroborate / methanol / 0 - 20 °C
2: triethylamine / dichloromethane / 0 - 20 °C
3: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.92 h / -78 °C / Inert atmosphere
4: lithium aluminium tetrahydride / diethyl ether / -40 °C
5: potassium phosphate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-cyclo-hexyl-phosphine / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Zhang, He; Zhou, Chang-Bing; Chen, Qing-Yun; Xiao, Ji-Chang; Hong, Ran
Organic Letters, 2011 , vol. 13, # 4 p. 560 - 563
反应条件
1: 89 percent / NaBH4 / methanol / Ambient temperature
2: 83 percent / SOCl2, pyridine / benzene / 2 h / Heating
3: zinc / ethanol / 10 h / Heating
View Scheme
参考文献
Eliseenkov,E.V. et al.
Zhurnal Organicheskoi Khimii, 1978 , vol. 14, p. 781 - 785,721 - 724
反应条件
boron trifluoride diethyl etherate; titanium tetrachloride; triethylamine
1.) Et2O, room temp., 1h; 2.) room temp.; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Wipf, Peter; Prewo, Roland; Bieri, Jost H.; Heimgartner, Heinz; Nastopoulos, Vassilios; Germain, Gabriel
Helvetica Chimica Acta, 1987 , vol. 70, p. 1380 - 1388
反应条件
(i) HCONH2, HCO2H, (ii) aq. HCl; Multistep reaction;
参考文献
Fuller; Molloy; Day; Roush; Marsh
Journal of medicinal chemistry, 1973 , vol. 16, # 2 p. 101 - 106
反应条件
1: 65 percent / BuLi / tetrahydrofuran / 0 - 25 °C
2: aq. K3Fe(CN)6, K2CO3, (DHQD)2-DPP, OsO4 / 2-methyl-propan-2-ol; toluene / 72 h / 0 °C
View Scheme
参考文献
Bennani; Vanhessche; Sharpless
Tetrahedron Asymmetry, 1994 , vol. 5, # 8 p. 1473 - 1476
