2-(2-氰基苯基)苯甲腈合成路线 （共 37 条）
反应条件
tetrabutylammomium bromide; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide
T=100°C; Heck reaction; 20 h;
参考文献
Dit Chabert, Jeremie Fournier; Joucla, Lionel; David, Emilie; Lemaire, Marc
Tetrahedron, 2004 , vol. 60, # 14 p. 3221 - 3230
反应条件
acetic anhydride; acetic acid
T=145°C;
参考文献
Underwood; Clough
Journal of the American Chemical Society, 1929 , vol. 51, p. 586
反应条件
pyridine
T=150°C; 6 h;
参考文献
Pletnev, Alexandre A.; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9428 - 9438
反应条件
copper
T=190 - 200°C; 18 h;
参考文献
Frohn, H. J.; Klose, A.; Bardin, V. V.
Journal of Fluorine Chemistry, 1993 , vol. 64, # 3 p. 201 - 216
反应条件
1: 4-methyl-chlorobenzene With iodine; magnesium in tetrahydrofuran; toluene
Grignard reaction; Inert atmosphereReflux;
2: ortho-chloro-benzonitrile With manganese (II) chloride in tetrahydrofuran; toluene
T=-5°C; Grignard reaction; 4 h;
参考文献
Qian, Haixia; Peng, Xinhua; Wu, Xiangrui
Asian Journal of Chemistry, 2010 , vol. 22, # 8 p. 6341 - 6344
反应条件
1: Cu
2: Py / dimethylformamide
View Scheme
参考文献
Cirigottis,K.A. et al.
Australian Journal of Chemistry, 1974 , vol. 27, p. 2209 - 2228
反应条件
pyridine in N,N-dimethyl-formamide
参考文献
Cirigottis,K.A. et al.
Australian Journal of Chemistry, 1974 , vol. 27, p. 2209 - 2228
参考文献
Forrest,J.
Journal of the Chemical Society, 1960 , p. 594 - 601
参考文献
Ege,G.; Beisiegel,E.
Synthesis, 1974 , p. 22 - 23
参考文献
Barton,J.W.; Grinham,A.R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972 , p. 634 - 637
