5-甲基环己烷-1,3-二酮合成路线 （共 53 条）
反应条件
sodium hydroxide; hydrogen in water T=50°C; P=93757.4 Torr; 5 h;
参考文献
Schinzer, Dieter; Fessner, Klaus; Ruppelt, Martin
Liebigs Annalen der Chemie, 1992 , # 2 p. 139 - 144
反应条件
sodium hydroxide 2 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; VAN DER VEEN, Lars; MC CONNELL, Darryl; SCHNEIDER, Siegfried; GRAUERT, Matthias; SCHOOP, Andreas; WUNBERG, Tobias
Patent: WO2010/122091 A1, 2010 ;
Location in patent: Page/Page column 15 ;
WO 2010/122091 A1
反应条件
hydrogenchloride T=80 - 90°C; 0.0833333 h; Yield given;
参考文献
Poldy, Jacqueline; Peakall, Rod; Barrow, Russell Allan
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 20 p. 4296 - 4300
反应条件
1: KOtBu / 2-methyl-propan-2-ol 2: (i) aq. EtOH, KOH, (ii) aq. HCl View Scheme
参考文献
Stork,G.; Tomasz,M.
Journal of the American Chemical Society, 1964 , vol. 86, p. 471 - 478
反应条件
1: MnO2 / CH2Cl2 2: KOtBu / 2-methyl-propan-2-ol 3: (i) aq. EtOH, KOH, (ii) aq. HCl View Scheme
参考文献
Stork,G.; Tomasz,M.
Journal of the American Chemical Society, 1964 , vol. 86, p. 471 - 478
反应条件
1: With potassium tert-butylate in tert-butyl alcohol 2: With hydrogenchloride in tetrahydrofuran; water Further stages.;
参考文献
Boers, Rutger B.; Gast, Peter; Hoff, Arnold J.; De Groot, Huub J. M.; Lugtenburg, Johan
European Journal of Organic Chemistry, 2002 , # 1 p. 189 - 202
反应条件
sodium hydride T=-10 - 20°C; Michael-Claisen cyclization; 1 h; Inert atmosphereneat (no solvent); regioselective reaction;
参考文献
Sharma, Dharminder; Shil, Arun K.; Singh, Bikram; Das, Pralay
Synlett, 2012 , vol. 23, # 8 p. 1199 - 1204
反应条件
sodium hydride T=-10 - 20°C; Michael-Claisen cyclization; 1 h; Inert atmosphereneat (no solvent); regioselective reaction;
参考文献
Sharma, Dharminder; Shil, Arun K.; Singh, Bikram; Das, Pralay
Synlett, 2012 , vol. 23, # 8 p. 1199 - 1204
反应条件
sodium hydride T=-10 - 20°C; Michael-Claisen cyclization; 1 h; Inert atmosphereneat (no solvent); regioselective reaction;
参考文献
Sharma, Dharminder; Shil, Arun K.; Singh, Bikram; Das, Pralay
Synlett, 2012 , vol. 23, # 8 p. 1199 - 1204
反应条件
sodium ethanolate in ethanol
参考文献
Tada, Masahiro; Takakuwa, Takako; Nagai, Masashi; Yoshii, Takao
Agricultural and Biological Chemistry, 1990 , vol. 54, # 11 p. 3061 - 3063
