5-氨基-1-苄基-1H-1,2,3-噻唑-4-羧胺合成路线 （共 18 条）
反应条件
1: cold 1N-potassium hydroxide 2: formamide / 1 h / 190 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2344 - 2351
反应条件
hydrogenchloride; trichlorophosphate 1.) DMF, 0 deg C, 5 min, 25 deg C, 10 min, 80 deg C, 15 min, 2.) DMF, water, 80 deg C, 5 min; Yield given. Multistep reaction;
参考文献
L'abbe, Gerrit; Godts, Francoise; Toppet, Suzanne
Bulletin des Societes Chimiques Belges, 1985 , vol. 94, # 7 p. 441 - 448
反应条件
1: 80 percent / acetone / 48 h / Heating 2: 90 percent / K2CO3 / acetone; methanol / 6 h / Heating 3: 60 percent / Cu(OAc)2, 1N aq. NaOH / 0.5 h / Heating View Scheme
参考文献
Sznaidman; Beauchamp
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1605 - 1610
反应条件
in ethanol 8 h; Heating; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 6 p. 1607 - 1609
参考文献
Russian Chemical Bulletin, , vol. 52, # 8 p. 1770 - 1776
反应条件
1: ethanol / 8 h / Heating 2: POCl3; N,N-diethylaniline / 6 h / 90 °C View Scheme
参考文献
Biagi, Giuliana; Bianucci, Anna Maria; Coi, Alessio; Costa, Barbara; Fabbrini, Laura; Giorgi, Irene; Livi, Oreste; Micco, Iolanda; Pacchini, Federica; Santini, Edoardo; Leonardi, Michele; Nofal, Fatena Ahmad; Salerni, Oreste LeRoy; Scartoni, Valerio
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4679 - 4693
反应条件
1: ethanol / 8 h / Heating
2: POCl3; N,N-diethylaniline / 6 h / 90 °C
View Scheme
参考文献
Biagi, Giuliana; Bianucci, Anna Maria; Coi, Alessio; Costa, Barbara; Fabbrini, Laura; Giorgi, Irene; Livi, Oreste; Micco, Iolanda; Pacchini, Federica; Santini, Edoardo; Leonardi, Michele; Nofal, Fatena Ahmad; Salerni, Oreste LeRoy; Scartoni, Valerio
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4679 - 4693
参考文献
Bochis; Chabala; Harris; Peterson; Barash; Beattie; Brown; Graham; Waksmunski; Tischler; Joshua; Smith; Colwell; Wyvratt Jr.; Fisher; Tamas; Nicolich; Schleim; Wilks et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2843 - 2852
