5-溴-6-氟-1H-吲哚合成路线 （共 3 条）
反应条件
copper(l) iodide in N,N-dimethyl-formamide
T=0 - 100°C; 4 h;
参考文献
H. Lundbeck A/S
Patent: US2012/252853 A1, 2012 ;
Location in patent: Page/Page column 26 ;
US 20120252853 A1
反应条件
1.1: acetic acid; N-iodo-succinimide / 3.5 h / 20 °C
1.2: pH 10
2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 2.5 h / 0 - 20 °C / Inert atmosphere
3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 80 °C / Inert atmosphere
View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao
Patent: WO2012/103806 A1, 2012 ;
WO 2012/103806 A1
反应条件
1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 2.5 h / 0 - 20 °C / Inert atmosphere
2: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 80 °C / Inert atmosphere
View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao
Patent: WO2012/103806 A1, 2012 ;
WO 2012/103806 A1
