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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
4350-51-0
合成路线
（共 8 条）
109-04-6
邻溴吡啶
+
150255-96-2
3-氰基苯硼酸
→
反应条件
4350-51-0
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in 1,4-dioxane; water T=90°C; Suzuki-Miyaura Coupling; 0.383333 h; Flow reactor;
参考文献
Christakakou, Maria; Schoen, Michael; Schnuerch, Michael; Mihovilovic, Marko D.
Synlett, 2013 , vol. 24, # 18 art. no. ST-2013-D0723-L, p. 2411 - 2418
6952-59-6
间溴苯腈
→
反应条件
4350-51-0
反应条件
1: meta-bromobenzonitrile With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Negishi coupling reaction; 0.5 h; 2: pyridin-2-ylzinc bromide in tetrahydrofuran T=65°C; Negishi coupling reaction; 16 h;
参考文献
Coleridge, Brian M.; Bello, Charles S.; Ellenberger, David H.; Leitner, Andreas
Tetrahedron Letters, 2010 , vol. 51, # 2 p. 357 - 359
69113-59-3
间碘苯腈
+
882521-96-2
→
反应条件
4350-51-0
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine; copper(l) iodide in tetrahydrofuran Suzuki-Miyaura cross-coupling reaction; Heating;
参考文献
Hodgson, Paul B.; Salingue, Fabrice H.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 685 - 687
69113-59-3
间碘苯腈
+
13737-04-7
2-三甲硅基吡啶
→
反应条件
4350-51-0
反应条件
tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; silver(l) oxide in tetrahydrofuran; N,N-dimethyl-formamide T=90°C; 18 h;
参考文献
Napier, Spencer; Marcuccio, Sebastian M.; Tye, Heather; Whittaker, Mark
Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6314 - 6315
766-84-7
3-氯苯腈
→
反应条件
4350-51-0
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=65°C; Negishi cross-coupling; 1.5 h; Inert atmosphere;
参考文献
Luzung, Michael R.; Patel, Jigar S.; Yin, Jingjun
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8330 - 8332
109-09-1
2-氯吡啶
+
766-84-7
3-氯苯腈
→
反应条件
4350-51-0
反应条件
manganese; NiBr2(2,2'-bipyridine); trifluoroacetic acid in N,N-dimethyl-formamide T=60°C; 6 h;
参考文献
Gosmini, Corinne; Bassene-Ernst, Carine; Durandetti, Muriel
Tetrahedron, 2009 , vol. 65, # 31 p. 6141 - 6146
109-04-6
邻溴吡啶
+
6952-59-6
间溴苯腈
→
反应条件
4350-51-0
反应条件
NiBr2bipy; tetra-n-butylammonium tetrafluoroborate in N,N-dimethyl-formamide Ambient temperatureelectrolysis;
参考文献
Gosmini, Corinne; Lasry, Sarah; Nedelec, Jean-Yves; Perichon, Jacques
Tetrahedron, 1998 , vol. 54, # 7 p. 1289 - 1298
109-04-6
邻溴吡啶
→
反应条件
4350-51-0
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 16 h / 20 °C 1.2: 75 percent / isopropanol / tetrahydrofuran; hexane / 4 h / Heating 2.1: 84 percent / Pd(OAc)2; K2CO3; Ph3P / CuI / tetrahydrofuran / Heating View Scheme
参考文献
Hodgson, Paul B.; Salingue, Fabrice H.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 685 - 687
