1-乙基-4-哌啶-4-基哌嗪合成路线 （共 4 条）
反应条件
hydrogenchloride in methanol; dichloromethane; isopropyl alcohol
T=20 - 40°C; 50 h; Reflux;
参考文献
Abott GmbH and Co KG
Patent: US2011/65720 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1.1: dichloromethane / 0.5 h / 0 - 20 °C
1.2: 0 - 20 °C
2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi
Patent: WO2013/160810 A2, 2013 ;
反应条件
1.1: dichloromethane / 0.5 h / 0 - 20 °C
1.2: 0 - 20 °C
2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PANDURANGA ADULLA, Reddy; PARTHASARADHI REDDY, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; PREM KUMAR, Mamnoor; BHASKAR REDDY, Kasireddy; NARSINGAM, Mogili; VENKATI, Mukkera; VL SUBRAHMANYAM, Lanka; MALLIKARJUN REDDY, Ravi
Patent: WO2013/160810 A2, 2013 ;
反应条件
1: acetic acid; sodium tris(acetoxy)borohydride / ethanol / 20 °C / Cooling with ice
2: hydrogenchloride / dichloromethane; isopropyl alcohol; methanol / 50 h / 20 - 40 °C / Reflux
View Scheme
参考文献
Abott GmbH and Co KG
Patent: US2011/65720 A1, 2011 ;
