(3-氯-2-氧代-2H-吡嗪-1-基)-乙酸乙酯合成路线 （共 5 条）
反应条件
oxalyl dichloride in N,N-dimethyl-formamide; acetonitrile T=40°C;
参考文献
Chung, John Y. L.; Cvetovich, Raymond J.; Tsay, Fuh-Rong; Dormer, Peter G.; DiMichele, Lisa; Mathre, David J.; Chilenski, Jennifer R.; Mao, Bing; Wenslow, Robert
Journal of Organic Chemistry, 2003 , vol. 68, # 23 p. 8838 - 8846
反应条件
1: 16 h / |Inert atmosphere; |Large scale 2: acetic acid; trifluoroacetic acid / 3.5 h / 78 °C / |Inert atmosphere; |Large scale 3: oxalyl dichloride; N,N-dimethyl-formamide / acetonitrile; isopropanol acetate / 2.5 h / 35 - 40 °C / |Inert atmosphere View Scheme
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
1: acetic acid; trifluoroacetic acid / 3.5 h / 78 °C / |Inert atmosphere; |Large scale 2: oxalyl dichloride; N,N-dimethyl-formamide / acetonitrile; isopropanol acetate / 2.5 h / 35 - 40 °C / |Inert atmosphere View Scheme
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
1: 16 h / |Inert atmosphere; |Large scale 2: acetic acid; trifluoroacetic acid / 3.5 h / 78 °C / |Inert atmosphere; |Large scale 3: trichlorophosphate / dichloromethane / |Inert atmosphere View Scheme
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
反应条件
1: acetic acid; trifluoroacetic acid / 3.5 h / 78 °C / |Inert atmosphere; |Large scale 2: trichlorophosphate / dichloromethane / |Inert atmosphere View Scheme
参考文献
Ashwood, Michael S.; Alabaster, Ramon J.; Cottrell, Ian F.; Cowden, Cameron J.; Davies, Antony J.; Dolling, Ulf H.; Emerson, Khateeta M.; Gibb, Andrew D.; Hands, David; Wallace, Debra J.; Wilson, Robert D.
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 192 - 200
