1: KOtBu / dimethylsulfoxide / 50 °C 2: NBS / dimethylformamide / 0 °C 3: 95 percent / Pd(OAc)2; dppp; KOAc / 20 h / 110 °C 4: 82 percent / H2 / Ru-Alox / ethyl acetate / 24 h / 60 °C 5: 97 percent / TMSCl; NaI / acetonitrile / 40 °C 6: pig liver esterase / 35 °C / pH 8.0 7: 81 percent / DPPA; Et3N / CH2Cl2 / 40 °C 8: DMAP / 20 °C 9: NaH / toluene / Heating 10: pyridine / CH2Cl2 / -10 °C 11: NaN3 / acetone; H2O / 20 °C 12: H2 / Ra-Co 13: Et3N 14: HBr; AcOH View Scheme

scandium tris(trifluoromethanesulfonate) T=80°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

scandium tris(trifluoromethanesulfonate) T=80°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

1: cyanide 2: 2.) H2O View Scheme

hydrogen cyanide