2-苯乙基-1,3-二氧戊环合成路线 （共 21 条）
反应条件
magnesium bromide in diethyl ether 0.5 h; Ambient temperature;
参考文献
PARK, Jung Ho; KIM, Sunggak
Chemistry Letters, 1989 , p. 629 - 632
反应条件
iron(III) chloride in dichloromethane 0.25 h; Ambient temperatureother reaction time, solvent, reagent; other amount of reagent; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 62, # 19 p. 6684 - 6686
反应条件
hydroxylamine hydrochloride; toluene-4-sulfonic acid in ethanol 2 h; Heating;
参考文献
Yamauchi
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 11 p. 2042 - 2043
反应条件
Oxonereg;; water in tetrahydrofuran T=0 - 20°C; Hydrolysis; oxidation; 12 h;
参考文献
Orita, Akihiro; Yaruva, Jayamma; Otera, Junzo
Angewandte Chemie - International Edition, 1999 , vol. 38, # 15 p. 2267 - 2270
反应条件
1: OXONE; H2O / tetrahydrofuran / 12 h / 0 - 20 °C 2: 99 percent / TfOH / 2 h / 5 - 20 °C View Scheme
参考文献
Orita, Akihiro; Yaruva, Jayamma; Otera, Junzo
Angewandte Chemie - International Edition, 1999 , vol. 38, # 15 p. 2267 - 2270
反应条件
1: trimethylsilyl-methylmagnesium chloride With zinc(II) iodide in diethyl ether Addition; 6 h; Heating; 2: 2-(2-phenylethyl)-1,3-dioxolane in benzene Grignard reaction; 8 h; Heating; Further stages.;
参考文献
Chiang, Chao-Cheng; Chen, Yu-Huei; Hsieh, Yu-Tsai; Luh, Tien-Yau
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4694 - 4697
反应条件
aluminum oxide
0.0333333 h; Irradiation;
参考文献
Moghaddam; Sharifi
Synthetic Communications, 1995 , vol. 25, # 16 p. 2457 - 2461
反应条件
(R,R)-TMCDA in tetrahydrofuran
T=25°C; 0.25 h;
参考文献
Ohmiya, Hirohisa; Yorimitsu, Hideki; Oshima, Koichiro
Journal of the American Chemical Society, 2006 , vol. 128, # 6 p. 1886 - 1889
反应条件
1: 2-lt;2-(phenylsulfonyl)ethylgt;-1,3-dioxolane With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Metallation; 0.5 h;
2: cyclohexenon With benzoyl chloride in tetrahydrofuran; hexane
T=-78 - 20°C; Addition; acylation; 3 h;
3: With potassium tert-butylate in tetrahydrofuran; hexane
Elimination; aromatization; 3 h; Heating;
参考文献
Orita, Akihiro; Yaruva, Jayamma; Otera, Junzo
Angewandte Chemie - International Edition, 1999 , vol. 38, # 15 p. 2267 - 2270
反应条件
P(t-Bu)2Me; tetrabutyl ammonium fluoride; palladium (II) bromide in tetrahydrofuran
T=20°C; Hiyama coupling; 14 h;
参考文献
Lee, Jae-Young; Fu, Gregory C.
Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5616 - 5617
