2-(4-溴苯基)-2-甲基-1,3-二氧戊环合成路线 （共 23 条）
反应条件
1.1: 9-bora-bicyclo[3.3.1]nonane / toluene / 18 h / |Inert atmosphere; |Reflux 1.2: 2 h / 20 °C / |Inert atmosphere; |Reflux 2.1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Soderquist, John A.; Kock, Iveliz; Estrella, Maria E.
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 1076 - 1079
反应条件
diiodo monosilane in chloroform-d1 T=22°C; 0.0333333 h; 2 equiv DIS; other temp. and mol percent; other ketals and acetals;
参考文献
Keinan, E.; Perez, D.; Sahai, M.; Shvily, R.
Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2927 - 2938
反应条件
1.1: n-butyllithium / petroleum ether / 1 h / -78 °C 1.2: 35 percent / petroleum ether; diethyl ether / 1 h / -78 °C 2.1: 80 percent / aq. perchloric acid / diethyl ether / 3 h / 20 °C View Scheme
参考文献
Bhanthumnavin; Bentrude
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 980 - 990
反应条件
1.1: 9-bora-bicyclo[3.3.1]nonane / toluene / 18 h / |Inert atmosphere; |Reflux 1.2: 2 h / 20 °C / |Inert atmosphere; |Reflux 2.1: sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran / 16 h / |Inert atmosphere; |Reflux 3.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium chlorite; sodium hypochlorite / water; acetonitrile; aq. phosphate buffer / 6 h / 20 - 35 °C / pH 6.7 / |Inert atmosphere View Scheme
参考文献
Soderquist, John A.; Kock, Iveliz; Estrella, Maria E.
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 1076 - 1079
反应条件
1.1: t-BuLi / tetrahydrofuran / 0.5 h / -76 °C 1.2: S / tetrahydrofuran / 3 h / -76 - 20 °C 1.3: tetrahydrofuran / 0.25 h / 20 °C 2.1: aq. HCl / acetone / 2 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 3 p. 473 - 476
反应条件
toluene-4-sulfonic acid in benzene
39 h; Heating;
参考文献
Yamakawa, Takeru; Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1430 - 1437
反应条件
trimethyl orthoformate in ethylene glycol; toluene
参考文献
Zeneca Limited; Zeneca PHARMA S A
Patent: US5332757 A1, 1994 ;
US 5332757 A
反应条件
toluene-4-sulfonic acid in ethylene glycol; toluene
参考文献
Sandoz, Inc.
Patent: US3953525 A1, 1976 ;
反应条件
Multistep reaction.;
参考文献
Spivey, Alan C.; Srikaran, Ratnasothy; Diaper, Christopher M.; Turner, David J.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 10 p. 1638 - 1640
反应条件
1.1: t-BuLi / tetrahydrofuran / 0.5 h / -76 °C
1.2: tetrahydrofuran / 2 h / -76 - 20 °C
2.1: aq. HCl / acetone / 2 h / Heating
View Scheme
参考文献
Comasseto, Joao V.; Omori, Alvaro T.; Porto, Andre L. M.; Andrade, Leandro H.
Tetrahedron Letters, 2004 , vol. 45, # 3 p. 473 - 476
