2-(4-溴苯基)-2-甲基-1,3-二氧戊环合成路线 （共 23 条）
反应条件
1: p-bromo-(2'-methyl-1',3'-dioxolan-2'-yl)-benzene With magnesium in tetrahydrofuran
Heating;
2: ethyl-α,α,α-trifluoroacetate T=-78°C;
3: With hydrogenchloride
T=20°C;
参考文献
Sasaki, Shigeru; Yamauchi, Takayasu; Kubo, Hajime; Kanai, Masatomi; Ishii, Akihiro; Higashiyama, Kimio
Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1497 - 1500
反应条件
1.1: Mg / tetrahydrofuran / Heating
1.2: -78 °C
1.3: 65 percent / aq. HCl / 20 °C
2.1: 99 percent / Et2Zn / hexane / 5 h / 20 °C
View Scheme
参考文献
Sasaki, Shigeru; Yamauchi, Takayasu; Kubo, Hajime; Kanai, Masatomi; Ishii, Akihiro; Higashiyama, Kimio
Tetrahedron Letters, 2005 , vol. 46, # 9 p. 1497 - 1500
参考文献
Sandoz, Inc.
Patent: US3998850 A1, 1976 ;
