4-(5-甲酰基-2-呋喃)-2-羟基苯甲酸合成路线 （共 4 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol
12 h; RefluxInert atmosphere;
参考文献
Tiberi, Marika; Tintori, Cristina; Ceresola, Elisa Rita; Fazi, Roberta; Zamperini, Claudio; Calandro, Pierpaolo; Franchi, Luigi; Selvaraj, Manikandan; Botta, Lorenzo; Sampaolo, Michela; Saita, Diego; Ferrarese, Roberto; Clementi, Massimo; Canducci, Filippo; Botta, Maurizio
Antimicrobial Agents and Chemotherapy, 2014 , vol. 58, # 6 p. 3043 - 3052
反应条件
1: 4-amino-2-hydroxybenzoic acid With tetrafluoroboric acid; sodium nitrite in water
T=0°C;
2: furfural With copper dichloride in water; acetone
T=20°C; Meerwein arylation;
参考文献
Rajamaki, Suvi; Innitzer, Anna; Falciani, Chiara; Tintori, Cristina; Christ, Frauke; Witvrouw, Myriam; Debyser, Zeger; Massa, Silvio; Botta, Maurizio
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 13 p. 3615 - 3618
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: water; sodium hydroxide / methanol / Reflux
View Scheme
参考文献
Rinaldi, Marta; Tintori, Cristina; Franchi, Luigi; Vignaroli, Giulia; Innitzer, Anna; Massa, Silvio; Este, Jose A.; Gonzalo, Encarna; Christ, Frauke; Debyser, Zeger; Botta, Maurizio
ChemMedChem, 2011 , vol. 6, # 2 p. 343 - 352
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: water; sodium hydroxide / methanol / Reflux
View Scheme
参考文献
Rinaldi, Marta; Tintori, Cristina; Franchi, Luigi; Vignaroli, Giulia; Innitzer, Anna; Massa, Silvio; Este, Jose A.; Gonzalo, Encarna; Christ, Frauke; Debyser, Zeger; Botta, Maurizio
ChemMedChem, 2011 , vol. 6, # 2 p. 343 - 352
