3-溴-5-(三氟甲基)吡啶合成路线 （共 13 条）
反应条件
(nBu)3MgLi in toluene T=-75°C; 0.25 h;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 16 h / 110 °C 2: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C View Scheme
反应条件
1: 3-bromo-5-(trifluoromethyl)pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-100 - -10°C;
2: methyl iodide in tetrahydrofuran
T=-78°C; 0.5 h;
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra
Patent: WO2010/149755 A1, 2010 ;
Location in patent: Page/Page column 154-155; 200 ;
WO 2010/149755 A1
