3-(4-氨基-1-萘)-n-boc-l-丙氨酸合成路线 （共 3 条）
反应条件
sodium hydroxide in methanol
T=20°C; 2.5 h;
参考文献
Szczepankiewicz, Bruce G.; Liu, Gang; Hajduk, Philip J.; Abad-Zapatero, Cele; Pei, Zhonghua; Xin, Zhili; Lubben, Thomas H.; Trevillyan, James M.; Stashko, Michael A.; Ballaron, Stephen J.; Liang, Heng; Huang, Flora; Hutchins, Charles W.; Fesik, Stephen W.; Jirousek, Michael R.
Journal of the American Chemical Society, 2003 , vol. 125, # 14 p. 4087 - 4096
反应条件
1.1: Zn / dimethylformamide / 0.25 h / 65 °C
1.2: 46 percent / Pd(OAc)2; tris(o-tolyl)phosphine / dimethylformamide / 1.5 h / 65 °C
2.1: 91 percent / aq. NaOH / methanol / 2.5 h / 20 °C
View Scheme
参考文献
Szczepankiewicz, Bruce G.; Liu, Gang; Hajduk, Philip J.; Abad-Zapatero, Cele; Pei, Zhonghua; Xin, Zhili; Lubben, Thomas H.; Trevillyan, James M.; Stashko, Michael A.; Ballaron, Stephen J.; Liang, Heng; Huang, Flora; Hutchins, Charles W.; Fesik, Stephen W.; Jirousek, Michael R.
Journal of the American Chemical Society, 2003 , vol. 125, # 14 p. 4087 - 4096
反应条件
1.1: Zn / dimethylformamide / 0.25 h / 65 °C
1.2: 46 percent / Pd(OAc)2; tris(o-tolyl)phosphine / dimethylformamide / 1.5 h / 65 °C
2.1: 91 percent / aq. NaOH / methanol / 2.5 h / 20 °C
View Scheme
参考文献
Szczepankiewicz, Bruce G.; Liu, Gang; Hajduk, Philip J.; Abad-Zapatero, Cele; Pei, Zhonghua; Xin, Zhili; Lubben, Thomas H.; Trevillyan, James M.; Stashko, Michael A.; Ballaron, Stephen J.; Liang, Heng; Huang, Flora; Hutchins, Charles W.; Fesik, Stephen W.; Jirousek, Michael R.
Journal of the American Chemical Society, 2003 , vol. 125, # 14 p. 4087 - 4096
