2-(4-甲基苯基)-1-丙醇合成路线 （共 24 条）
反应条件
1: With sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran
T=0 - 20°C; Addition; 2.5 h;
2: With anhydrous potassium sulfate; potassium hydrogensulfate; oxone in water
T=0 - 20°C; Oxidation;
参考文献
Pfizer Products Inc.
Patent: EP1167329 A2, 2002 ;
Location in patent: Page 8 ;
反应条件
1: With [RhCl(η2:η2-cycloocta-1,5-diene)]2; N,N,N',N'-tetramethyl-1,4-butanediamine in acetonitrile
P=10351 Torr; Autoclave;
2: With hydrogen in acetonitrile
T=60°C; P=10351 Torr; 21 h; Autoclave;
参考文献
Cheung, Lawrence L. W.; Vasapollo, Giuseppe; Alper, Howard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 10 p. 2019 - 2022
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Bokel, H. H.; Hoppmann, A.; Weyerstahl, P.
Tetrahedron, 1980 , vol. 36, # 5 p. 651 - 654
反应条件
lithium aluminium tetrahydride in diethyl ether
1.5 h; Ambient temperature;
参考文献
Matsumoto; Ishida; Yoshida; Terao; Takeda; Asakawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 7 p. 1721 - 1726
反应条件
triethylsilane; trifluoroacetic acid
T=25°C; 3 h;
参考文献
Chavan, Subhash P.; Khatod, Harshali S.
Tetrahedron: Asymmetry, 2012 , vol. 23, # 18-19 p. 1410 - 1415,6
反应条件
RhH(CO)(triphenylphosphine)3; sodium tetrahydroborate; isopropyl alcohol in dichloromethane
T=100°C; P=25857.4 Torr; 22 h; Yield given. Yields of byproduct given;
参考文献
Zhou, Jian-Qiang; Alper, Howard
Journal of the Chemical Society, Chemical Communications, 1991 , # 4 p. 233 - 234
反应条件
lithium aluminium tetrahydride in diethyl ether
T=20°C; Reduction;
参考文献
Chounan, Yukiyasu; Ono, Yasuo; Nishii, Shinji; Kitahara, Haruo; Ito, Shoei; Yamamoto, Yoshinori
Tetrahedron, 2000 , vol. 56, # 18 p. 2821 - 2831
反应条件
1: 88 percent / pyridine, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h / 20 °C
2: 38 percent / Li/NH3(liquid) / diethyl ether / 3 h / excess Li
View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
反应条件
ammonia; lithium in diethyl ether
3 h; excess Li;
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
反应条件
1: 96.4 percent / 2percent aq. sulfuric acid / 1.33 h / Heating
2: 1.) tetrahydrofuran-borane, 2.) 12percent sodium hydroxide, 30percent hydrogen peroxide / 1.) 0 - 5 deg C, 3 h, 2.) -5 - 0 deg C, 30 min, 3.) RT, 1 h
View Scheme
参考文献
Matsumoto; Ishida; Yoshida; Terao; Takeda; Asakawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 7 p. 1721 - 1726
