7-氯-2-(4-氟苯基)吡唑并[1,5-a]吡啶合成路线 （共 8 条）
反应条件
triethylamine; trifluoroacetic anhydride in ethylene glycol dimethyl ether
参考文献
Chamberlain, Stanley D.; Gudmundsson, Kristjan; Johns, Brian A.
Patent: US2004/72853 A1, 2004 ;
反应条件
iron(II) chloride in ethylene glycol dimethyl ether
3 h; Heating;
参考文献
Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Jung, David K.; Sexton, Connie J.; Boyd Jr., F. Leslie; Peel, Michael R.
Tetrahedron, 2003 , vol. 59, # 45 p. 9001 - 9011
反应条件
1: 66 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 15 h / 45 °C
2: 86 percent / hydroxylamine hydrochloride; aq. NaOH / methanol / 2 h / Heating
3: 1,2-dimethoxy-ethane / 0 - 15 °C
4: Et3N / 1,2-dimethoxy-ethane / 2 h / 4 - 20 °C
5: 69.7 g / FeCl2 / 1,2-dimethoxy-ethane / 3 h / Heating
View Scheme
参考文献
Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Jung, David K.; Sexton, Connie J.; Boyd Jr., F. Leslie; Peel, Michael R.
Tetrahedron, 2003 , vol. 59, # 45 p. 9001 - 9011
反应条件
1: 66 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 15 h / 45 °C
2: 86 percent / hydroxylamine hydrochloride; aq. NaOH / methanol / 2 h / Heating
3: 1,2-dimethoxy-ethane / 0 - 15 °C
4: Et3N / 1,2-dimethoxy-ethane / 2 h / 4 - 20 °C
5: 69.7 g / FeCl2 / 1,2-dimethoxy-ethane / 3 h / Heating
View Scheme
参考文献
Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Jung, David K.; Sexton, Connie J.; Boyd Jr., F. Leslie; Peel, Michael R.
Tetrahedron, 2003 , vol. 59, # 45 p. 9001 - 9011
反应条件
1: 86 percent / hydroxylamine hydrochloride; aq. NaOH / methanol / 2 h / Heating
2: 1,2-dimethoxy-ethane / 0 - 15 °C
3: Et3N / 1,2-dimethoxy-ethane / 2 h / 4 - 20 °C
4: 69.7 g / FeCl2 / 1,2-dimethoxy-ethane / 3 h / Heating
View Scheme
参考文献
Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Jung, David K.; Sexton, Connie J.; Boyd Jr., F. Leslie; Peel, Michael R.
Tetrahedron, 2003 , vol. 59, # 45 p. 9001 - 9011
反应条件
1: 1,2-dimethoxy-ethane / 0 - 15 °C
2: Et3N / 1,2-dimethoxy-ethane / 2 h / 4 - 20 °C
3: 69.7 g / FeCl2 / 1,2-dimethoxy-ethane / 3 h / Heating
View Scheme
参考文献
Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Jung, David K.; Sexton, Connie J.; Boyd Jr., F. Leslie; Peel, Michael R.
Tetrahedron, 2003 , vol. 59, # 45 p. 9001 - 9011
反应条件
acetic anhydride in toluene
参考文献
Chamberlain, Stanley D.; Gudmundsson, Kristjan; Johns, Brian A.
Patent: US2004/72853 A1, 2004 ;
反应条件
boron trifluoride diethyl etherate in toluene
3.5 h; Heating;
参考文献
Johns, Brian A.; Gudmundsson, Kristjan S.; Turner, Elizabeth M.; Allen, Scott H.; Samano, Vicente A.; Ray, John A.; Freeman, George A.; Boyd Jr., F. Leslie; Sexton, Connie J.; Selleseth, Dean W.; Creech, Katrina L.; Moniri, Kelly R.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2397 - 2411
