7-氯-2-(4-甲氧基苯基)吡唑并[1,5-a]吡啶合成路线 （共 5 条）
反应条件
triethylamine; trifluoroacetic anhydride in ethylene glycol dimethyl ether
参考文献
Chamberlain, Stanley D.; Gudmundsson, Kristjan; Johns, Brian A.
Patent: US2004/72853 A1, 2004 ;
反应条件
1: With triethylamine; trifluoroacetic anhydride in ethylene glycol dimethyl ether
T=0 - 20°C;
2: With iron(II) chloride in ethylene glycol dimethyl ether
8 h; Heating;
参考文献
Gudmundsson, Kristjan S.; Johns, Brian A.; Wang, Zhicheng; Turner, Elizabeth M.; Allen, Scott H.; Freeman, George A.; Boyd Jr., F. Leslie; Sexton, Connie J.; Selleseth, Dean W.; Moniri, Kelly R.; Creech, Katrina L.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 18 p. 5346 - 5361
反应条件
1.1: 97 percent / hydroxylamine hydrochloride; NaOH / methanol; H2O / Heating
2.1: frifluoroacetic anhydride; triethylamine / 1,2-dimethoxy-ethane / 0 - 20 °C
2.2: 52 percent / iron(II) chloride / 1,2-dimethoxy-ethane / 8 h / Heating
View Scheme
参考文献
Gudmundsson, Kristjan S.; Johns, Brian A.; Wang, Zhicheng; Turner, Elizabeth M.; Allen, Scott H.; Freeman, George A.; Boyd Jr., F. Leslie; Sexton, Connie J.; Selleseth, Dean W.; Moniri, Kelly R.; Creech, Katrina L.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 18 p. 5346 - 5361
反应条件
1.1: 86 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0 - 45 °C
2.1: 97 percent / hydroxylamine hydrochloride; NaOH / methanol; H2O / Heating
3.1: frifluoroacetic anhydride; triethylamine / 1,2-dimethoxy-ethane / 0 - 20 °C
3.2: 52 percent / iron(II) chloride / 1,2-dimethoxy-ethane / 8 h / Heating
View Scheme
参考文献
Gudmundsson, Kristjan S.; Johns, Brian A.; Wang, Zhicheng; Turner, Elizabeth M.; Allen, Scott H.; Freeman, George A.; Boyd Jr., F. Leslie; Sexton, Connie J.; Selleseth, Dean W.; Moniri, Kelly R.; Creech, Katrina L.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 18 p. 5346 - 5361
反应条件
1.1: 86 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0 - 45 °C
2.1: 97 percent / hydroxylamine hydrochloride; NaOH / methanol; H2O / Heating
3.1: frifluoroacetic anhydride; triethylamine / 1,2-dimethoxy-ethane / 0 - 20 °C
3.2: 52 percent / iron(II) chloride / 1,2-dimethoxy-ethane / 8 h / Heating
View Scheme
参考文献
Gudmundsson, Kristjan S.; Johns, Brian A.; Wang, Zhicheng; Turner, Elizabeth M.; Allen, Scott H.; Freeman, George A.; Boyd Jr., F. Leslie; Sexton, Connie J.; Selleseth, Dean W.; Moniri, Kelly R.; Creech, Katrina L.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 18 p. 5346 - 5361
