5,8,11,14-四氧杂-2-氮杂十六碳二酸 1-芴甲基酯合成路线 （共 8 条）
反应条件
trifluoroacetic acid in dichloromethane
1.5 h;
参考文献
N.V. ORGANON
Patent: WO2007/42469 A2, 2007 ;
Location in patent: Page/Page column 15; 16 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water
T=0 - 20°C; pH=8;
参考文献
Bogdan, Niculina D.; Matache, Mihaela; Meier, Veronika M.; Dobrotae, Cristian; Dumitru, Ioana; Roiban, Gheorghe D.; Funeriu, Daniel P.
Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2170 - 2180
反应条件
potassium carbonate in water
T=20°C; 16.75 h;
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
1: sodium hydroxide
2: sodium azide / N,N-dimethyl-formamide / 20 °C
3: palladium on carbon; hydrogen / tetrahydrofuran
4: dichloromethane
5: sodium hydroxide / tetrahydrofuran; toluene / 45 °C
6: hydrogenchloride; water / 1 h
7: potassium carbonate / water / 16.75 h / 20 °C
View Scheme
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
1: sodium azide / N,N-dimethyl-formamide / 20 °C
2: palladium on carbon; hydrogen / tetrahydrofuran
3: dichloromethane
4: sodium hydroxide / tetrahydrofuran; toluene / 45 °C
5: hydrogenchloride; water / 1 h
6: potassium carbonate / water / 16.75 h / 20 °C
View Scheme
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
1: dichloromethane
2: sodium hydroxide / tetrahydrofuran; toluene / 45 °C
3: hydrogenchloride; water / 1 h
4: potassium carbonate / water / 16.75 h / 20 °C
View Scheme
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
1: palladium on carbon; hydrogen / tetrahydrofuran
2: dichloromethane
3: sodium hydroxide / tetrahydrofuran; toluene / 45 °C
4: hydrogenchloride; water / 1 h
5: potassium carbonate / water / 16.75 h / 20 °C
View Scheme
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
1: sodium hydroxide / tetrahydrofuran; toluene / 45 °C
2: hydrogenchloride; water / 1 h
3: potassium carbonate / water / 16.75 h / 20 °C
View Scheme
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
