1-(2-氯苯基)-5-(2-呋喃)-3-(三氟甲基)-1H-吡唑合成路线 （共 3 条）
反应条件
1: in acetic acid
T=80°C; 18 h;
2: With sodium hydroxide in water; ethyl acetate
参考文献
EXELIXIS, INC.
Patent: WO2008/73825 A1, 2008 ;
Location in patent: Page/Page column 134 ;
WO 2008/073825 A1
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C
2: acetic acid / 18 h / 80 °C
View Scheme
参考文献
EXELIXIS, INC.
Patent: WO2008/73825 A1, 2008 ;
WO 2008/073825 A1
反应条件
sodium acetate; acetic acid
Heating;
参考文献
Lahm, George P.; Selby, Thomas P.; Freudenberger, John H.; Stevenson, Thomas M.; Myers, Brian J.; Seburyamo, Gilles; Smith, Ben K.; Flexner, Lindsey; Clark, Christopher E.; Cordova, Daniel
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4898 - 4906
