4-(4-氨基苯基)吗啉-3-酮合成路线 （共 14 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; water T=40°C; P=1500.15 Torr; 17 h;
参考文献
Mederski, Werner W.K.R.; Wendel, Peter Ludwig; Woissyk, Markus
Heterocycles, 2007 , vol. 74, # C p. 437 - 445
反应条件
potassium carbonate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in 1,4-dioxane T=110°C;
参考文献
PORTOLA PHARMACEUTICALS, INC.
Patent: WO2006/63293 A2, 2006 ;
Location in patent: Page/Page column 43 ;
WO 2006/063293 A2
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in toluene Inert atmosphereReflux;
参考文献
Al-Horani, Rami A.; Mehta, Akul Y.; Desai, Umesh R.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 771 - 783
反应条件
1: sodium hydroxide / ethanol; water / 0.5 h / 38 - 45 °C / pH 10 - 13 / Industry scale 2: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 3: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C View Scheme
参考文献
Li, Chao; Liu, Yingshuai; Zhang, Yongjun; Zhang, Xingxian
Journal of Chemical Research, 2011 , vol. 35, # 7 p. 400 - 401
反应条件
1: nitric acid; sulfuric acid / sulfolane / 2 h / -5 - 30 °C 2: hydrogen / Raney Ni / methanol / 24 h / 40 - 50 °C View Scheme
参考文献
Li, Chao; Liu, Yingshuai; Zhang, Yongjun; Zhang, Xingxian
Journal of Chemical Research, 2011 , vol. 35, # 7 p. 400 - 401
反应条件
in ethanol; ethyl acetate
参考文献
Aventis Pharma Deutschland GmbH
Patent: EP1571154 A1, 2005 ;
反应条件
1: toluene / 5 h / 95 °C 2: K2CO3 / acetonitrile / 8 h / 20 °C 3: H2 / Pd/C / methanol / 1 h / 35 °C / 750.06 Torr View Scheme
参考文献
Mederski, Werner W.K.R.; Cezanne, Bertram; Amsterdam, Christoph Van; Buehring, Karl-Ulrich; Dorsch, Dieter; Gleitz, Johannes; Maerz, Joachim; Tsaklakidis, Christos
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5817 - 5822
反应条件
1: K2CO3 / acetonitrile / 8 h / 20 °C 2: H2 / Pd/C / methanol / 1 h / 35 °C / 750.06 Torr View Scheme
参考文献
Mederski, Werner W.K.R.; Cezanne, Bertram; Amsterdam, Christoph Van; Buehring, Karl-Ulrich; Dorsch, Dieter; Gleitz, Johannes; Maerz, Joachim; Tsaklakidis, Christos
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5817 - 5822
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in N,N-dimethyl-formamide T=80°C; 12 h;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; VENKAT REDDY, Buthukuri
Patent: WO2013/46211 A1, 2013 ;
Location in patent: Page/Page column 51; 52 ;
反应条件
1: 92 percent / ethanol; H2O / 27 h / Heating 2: 87 percent / 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / 60 °C 3: aq. MeNH2 / ethanol / 1 h / Heating 4: 86 percent / pyridine / 1 h / 20 °C View Scheme
参考文献
ENANTIA, S.L.; RAFECAS JANE, Llorenc; COMELY, Alexander Christian; FERRALI, Alessandro; AMELA CORTES, Celia; PASTO AGUILA, Mireia
Patent: WO2011/80341 A1, 2011 ;
