5-甲氧基吲哚-2-羧酸合成路线 （共 29 条）
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Cruces, M. A.; Elorriaga, C.; Fernandez-Alvarez, E.; Lopez, O. Nieto
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 257 - 265
反应条件
sodium hydroxide Heating;
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 45 percent / methanol / -10 °C 2: 37 percent / xylene / Heating 3: 99 percent / aq. NaOH / Heating View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: sodium nitrite; hydrogenchloride / water / 1.17 h / 0 °C / |Inert atmosphere 2: sodium acetate / water; ethanol / 2 h / 0 °C / |Inert atmosphere 3: hydrogenchloride; water / ethanol / |Inert atmosphere 4: hydrogenchloride / water / 2.25 h / |Inert atmosphere; |Reflux 5: potassium hydroxide; water / 1 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Bessard, Yves
Organic Process Research and Development, 1998 , vol. 2, # 4 p. 214 - 220
反应条件
1: sodium carbonate; triethylamine / water; methanol / 2.5 h / 0 °C / |Inert atmosphere 2: sodium ethanolate; ethanol / ethanol / 0.25 h / 25 - 30 °C / |Inert atmosphere 3: hydrogenchloride / water / 2.25 h / |Inert atmosphere; |Reflux 4: potassium hydroxide; water / 1 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Bessard, Yves
Organic Process Research and Development, 1998 , vol. 2, # 4 p. 214 - 220
反应条件
1: hydrogenchloride; water / ethanol / |Inert atmosphere 2: hydrogenchloride / water / 2.25 h / |Inert atmosphere; |Reflux 3: potassium hydroxide; water / 1 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Bessard, Yves
Organic Process Research and Development, 1998 , vol. 2, # 4 p. 214 - 220
反应条件
1: hydrogenchloride / water / 2.25 h / |Inert atmosphere; |Reflux 2: potassium hydroxide; water / 1 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Bessard, Yves
Organic Process Research and Development, 1998 , vol. 2, # 4 p. 214 - 220
参考文献
Blaikie; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 313
反应条件
1: sulfuric acid / Reflux 2: trichlorophosphate / 20 °C View Scheme
参考文献
Lee, Jae Hong; So, Ju-Hoon; Jeon, Jong Hyun; Choi, Eun Bok; Lee, Yu-Ri; Chang, Young-Tae; Kim, Cheol-Hee; Bae, Myung Ae; Ahn, Jin Hee
Chemical Communications, 2011 , vol. 47, # 26 p. 7500 - 7502
反应条件
1: 89 percent / thionyl chloride / 4 h / Heating 2: 98 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Zhang, Lei; Zhao, Fei; Zheng, Mingyue; Zhai, Yun; Liu, Hong
Chemical Communications, 2013 , vol. 49, # 28 p. 2894 - 2896
