7-二氟甲基-5-甲基-吡唑并-[1,5-a]嘧啶-3-羧酸合成路线 （共 2 条）
反应条件
water; sodium hydroxide in methanol
T=80°C; 3 h;
参考文献
Patnaik, Samarjit; Zheng, Wei; Choi, Jae H.; Motabar, Omid; Southall, Noel; Westbroek, Wendy; Lea, Wendy A.; Velayati, Arash; Goldin, Ehud; Sidransky, Ellen; Leister, William; Marugan, Juan J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5734 - 5748
反应条件
1: acetic acid / 110 °C
2: water; sodium hydroxide / methanol / 3 h / 80 °C
View Scheme
参考文献
Patnaik, Samarjit; Zheng, Wei; Choi, Jae H.; Motabar, Omid; Southall, Noel; Westbroek, Wendy; Lea, Wendy A.; Velayati, Arash; Goldin, Ehud; Sidransky, Ellen; Leister, William; Marugan, Juan J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5734 - 5748
