2-甲基-1-苯基-2-丙烯-1-醇合成路线 （共 11 条）
反应条件
1: 84 percent / (+)-DIPT, Ti(OiPr)4, t-BuOOH, molecular sieves 4 Angstroem / CH2Cl2 / -34 °C 2: 94 percent / NEt3, 4-dimethylaminopyridine / CH2Cl2 / -10 °C 3: 82 percent / Te-rongalite, aq. NaOH / tetrahydrofuran / 11 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 3 p. 718 - 731
反应条件
1: 94 percent / NEt3, 4-dimethylaminopyridine / CH2Cl2 / -10 °C 2: 82 percent / Te-rongalite, aq. NaOH / tetrahydrofuran / 11 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 3 p. 718 - 731
反应条件
Chiracel OD-H column in hexanes; ethanol; carbon dioxide Product distribution / selectivity;
参考文献
WO2012/51036 A1, ;
Page/Page column 116 ;
WO 2012/051036 A1
反应条件
1: tri(isopropenyl)bismuthane With dimethyl zinc in diethyl ether; hexane 1 h; Heating; 2: benzaldehyde in diethyl ether; hexane T=0°C; 12 h; Further stages. Title compound not separated from byproducts.;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 22 p. 2638 - 2642
反应条件
1: di(1-methyl-ethylene)zinc With diethylzinc in toluene T=20°C; 0.166667 h; 2: With (–)-MIB in toluene T=20°C; 0.166667 h; 3: benzaldehyde in toluene T=-20°C; 16 h; optical yield given as percent eeenantioselective reaction;
参考文献
Synthesis, , # 15 art. no. Z07810SS, p. 2643 - 2651
反应条件
1: (±)-2-methyl-1-phenylprop-2-en-1-ol With Fc-PIP; N-ethyl-N,N-diisopropylamine in toluene T=0°C; 0.0833333 h; 2: propionic acid anhydride in toluene T=0°C; optical yield given as percent eeenantioselective reaction;
参考文献
Chinese Journal of Chemistry, , vol. 30, # 6 p. 1289 - 1294
参考文献
Kanemoto, Shigekazu; Shimuzu, Makoto; Yoshioka, Hirosuke
Tetrahedron Letters, 1987 , vol. 28, # 50 p. 6313 - 6316
反应条件
1.1: n-butyllithium 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux 3.1: acetic anhydride / 5 h / 80 °C / Inert atmosphere 4.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0 °C / Inert atmosphere 5.1: Fc-PIP; N-ethyl-N,N-diisopropylamine / toluene / 0.08 h / 0 °C 5.2: 0 °C View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 30, # 6 p. 1289 - 1294
反应条件
1.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0 °C / Inert atmosphere 2.1: Fc-PIP; N-ethyl-N,N-diisopropylamine / toluene / 0.08 h / 0 °C 2.2: 0 °C View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 30, # 6 p. 1289 - 1294
反应条件
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Reflux 2.1: acetic anhydride / 5 h / 80 °C / Inert atmosphere 3.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0 °C / Inert atmosphere 4.1: Fc-PIP; N-ethyl-N,N-diisopropylamine / toluene / 0.08 h / 0 °C 4.2: 0 °C View Scheme
参考文献
Chinese Journal of Chemistry, , vol. 30, # 6 p. 1289 - 1294
