(3-苯并[1,3]二氧代-5-异噁唑-5-基)-甲醇合成路线 （共 5 条）
反应条件
1: piperonal oxime With pyridine; N-chloro-succinimide in tetrahydrofuran
T=60°C; 0.5 h;
2: propargyl alcohol With triethylamine in tetrahydrofuran
T=50°C; 2 h;
参考文献
Jung, Hee Kyung; Doddareddy, Munikumar Reddy; Cha, Joo Hwan; Rhim, Hyewhon; Cho, Yong Seo; Koh, Hun Yeong; Jung, Bong Young; Pae, Ae Nim
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 3965 - 3970
反应条件
1: propargyl alcohol With 4-(N,N-dimethlyamino)pyridine; PEG-OCOCH2CH2COOH; dicyclohexyl-carbodiimide in dichloromethane
T=20°C; 16 h;
2: N-hydroxy-benzo[1,3]dioxole-5-carboximidoyl chloride With triethylamine in dichloromethane
T=20°C;
3: With sodium hydroxide
T=20°C; 3 h;
参考文献
Shang, Yong-Jia; Wang, Yan-Guang
Synthesis, 2002 , # 12 p. 1663 - 1668
反应条件
1.1: NH2OH*HCl; Na2CO3 / ethanol; H2O / 1 h / 60 °C
2.1: N-chlorosuccinimide; pyridine / tetrahydrofuran / 0.5 h / 60 °C
2.2: triethylamine / tetrahydrofuran / 2 h / 50 °C
View Scheme
参考文献
Jung, Hee Kyung; Doddareddy, Munikumar Reddy; Cha, Joo Hwan; Rhim, Hyewhon; Cho, Yong Seo; Koh, Hun Yeong; Jung, Bong Young; Pae, Ae Nim
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 3965 - 3970
反应条件
1.1: N-chlorosuccinimide / CH2Cl2
2.1: DCC; DMAP; PEG-OCOCH2CH2COOH / CH2Cl2 / 16 h / 20 °C
2.2: Et3N / CH2Cl2 / 20 °C
2.3: aq. NaOH / 3 h / 20 °C
View Scheme
参考文献
Shang, Yong-Jia; Wang, Yan-Guang
Synthesis, 2002 , # 12 p. 1663 - 1668
反应条件
silica gel; pyridinium chlorochromate in dichloromethane
5 h;
参考文献
Landge, Kamalkishor P.; Oh, Ji Seon; Pae, Ae Nim; Park, Woo Kyu; Gong, Jae Yang; Koh, Hun Yeong; Jung, Sun Ho
Bulletin of the Korean Chemical Society, 2011 , vol. 32, # 7 p. 2449 - 2452
