2-氨基-3-甲基苯甲酸合成路线 （共 84 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; P=760 Torr;
参考文献
Montoya-Pelaez, Pedro J.; Uh, Yoon-Seo; Lata, Christopher; Thompson, Matthew P.; Lemieux, Robert P.; Crudden, Cathleen M.
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 5921 - 5929
反应条件
sodium hydroxide; dihydrogen peroxide
参考文献
Lamara; Redhouse; Smalley; Thompson
Tetrahedron, 1994 , vol. 50, # 18 p. 5515 - 5525
反应条件
1: 46 percent / HNO3 / 1 h / -10 °C 2: 99 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr View Scheme
参考文献
Kanoh, Shigeyoshi; Muramoto, Hiroki; Kobayashi, Natsumi; Motoi, Masatoshi; Suda, Hiroshi
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 10 p. 3659 - 3662
反应条件
lithium hydroxide in water; benzene
参考文献
Edge, Simon J.; Ollis, W. David; Stephanatou, Julia Stephanidou; Stoddart, J. Fraser
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 8 p. 1701 - 1714
反应条件
1: 86percent H2SO4 / 1) 55 deg C, 10 min, 2) 75 deg C, 30 min 2: H2O2, NaOH View Scheme
参考文献
Zhao, Yu; Xiong, Li-Xia; Xu, Li-Ping; Wang, Hongxue; Xu, Han; Li, Hua-Bin; Tong, Jun; Li, Zheng-Ming
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3071 - 3088
反应条件
1.1: sodium sulfate / water / 40 °C 1.2: |Reflux 2.1: sulfuric acid / 0.33 h / 80 °C 3.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 50 °C View Scheme
参考文献
Zhao, Yu; Xiong, Li-Xia; Xu, Li-Ping; Wang, Hongxue; Xu, Han; Li, Hua-Bin; Tong, Jun; Li, Zheng-Ming
Research on Chemical Intermediates, 2013 , vol. 39, # 7 p. 3071 - 3088
反应条件
1: sulfuric acid / water / 2 h / 55 - 60 °C 2: ozone / methanol / 1.5 h / 785.91 Torr / |Cooling with acetone-dry ice 3: hydrogenchloride / water / 4 h / |Reflux 4: Pseudomonas fluorescens kynureninase / aq. phosphate buffer / 37 °C / pH 8 / |Enzymatic reaction View Scheme
参考文献
Maitrani, Chandan; Phillips, Robert S.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4670 - 4677
反应条件
1: hydrogenchloride / water / 4 h / |Reflux 2: Pseudomonas fluorescens kynureninase / aq. phosphate buffer / 37 °C / pH 8 / |Enzymatic reaction View Scheme
参考文献
Maitrani, Chandan; Phillips, Robert S.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4670 - 4677
反应条件
lithium hydroxide in water; benzene Title compound not separated from byproducts;
参考文献
Edge, Simon J.; Ollis, W. David; Stephanatou, Julia Stephanidou; Stoddart, J. Fraser
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 8 p. 1701 - 1714
参考文献
Dokunichin; Gaewa
Zhurnal Obshchei Khimii, 1953 , vol. 23, p. 606,609; engl. Ausg. S. 629, 632
