2-氨基-3-甲基苯甲酸合成路线 （共 84 条）
反应条件
in tetrahydrofuran T=-10 - 25°C; 19 h;
参考文献
EISAI CO., LTD.
Patent: WO2005/118565 A1, 2005 ;
Location in patent: Page/Page column 81 ;
反应条件
iodine; isopentyl nitrite in 1,4-dioxane; chloroform-d1 Heating;
参考文献
Perry, Robert J.; Turner, S. Richard
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6573 - 6579
反应条件
1: With sulfuric acid in water T=25°C; 0.2 h; 2: With sodium nitrite in water T=0°C; 1.5 h; 3: With potassium iodide in water T=25°C; 12 h;
参考文献
Moorthy, Jarugu Narasimha; Senapati, Kalyan; Parida, Keshaba Nanda; Jhulki, Samik; Sooraj, Kunnikuruvan; Nair, Nisanth N.
Journal of Organic Chemistry, 2011 , vol. 76, # 23 p. 9593 - 9601
反应条件
hydrogenchloride; sodium sulfide; sodium hydroxide; sodium nitrite Multistep reaction;
参考文献
Zheng, Jiahui; Liu, Xiaoqian; Yuan, Qing; Shin, Yoon-Joo; Sun, Daekyu; Lu, Yixin
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 6 p. 1293 - 1295
反应条件
1: isoamyl nitrite 2: HCl / methanol View Scheme
参考文献
Batt, Douglas G.; Jones, David G.; Greca, Susan La
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6704 - 6708
反应条件
1.1: H2SO4 / H2O / 1 h / 20 °C 1.2: NaNO2 / H2O / 1.5 h / 10 °C 1.3: 84 percent / KI; Cu powder / H2O / 30 °C 2.1: 90 percent / SOCl2 / 3 h / Heating 3.1: 93 percent / Cu / dimethylformamide / 5.5 h / Heating 4.1: 100 percent / LiAlH4 / diethyl ether / 5 h / Heating View Scheme
参考文献
Newman,M.S.; Lilje,K.C.
Journal of Organic Chemistry, 1979 , vol. 44, # 26 p. 4944 - 4946
反应条件
aluminium trichloride; lithium aluminium deuteride in diethyl ether
参考文献
Eibler, E.; Kaesbauer, J.; Pohl, H.; Sauer, J.
Tetrahedron Letters, 1987 , vol. 28, # 10 p. 1097 - 1100
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide T=75°C; 1 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 53, # 4 p. 388 - 391
参考文献
American Chemical Journal, , vol. 44, p. 124,508
反应条件
1: 42 percent / HCl (gas) / 18 h / Heating 2: Et3N / toluene / Ambient temperature 3: 87 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
