2-氨基-3-甲基苯甲酸合成路线 （共 84 条）
反应条件
methanimidamide monoacetate T=160°C; 16 h;
参考文献
MERCK PATENT GMBH; HUCK, Bayard R.; CHEN, Xiaoling; XIAO, Yufang; LAN, Ruoxi; DE SELM, Lizbeth Celeste; NEAGU, Constantin; POTNICK, Justin; KARRA, Srinivasa, R.; JOHNSON, Theresa, L.
Patent: WO2013/96194 A1, 2013 ;
Location in patent: Page/Page column 28-29 ;
参考文献
Merck and Co., Inc.
Patent: US5401745 A1, 1995 ;
反应条件
1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 70 °C / Inert atmosphere 2: N,N-dimethyl-formamide / 24 h / 150 °C View Scheme
参考文献
Nathubhai, Amit; Patterson, Richard; Woodman, Timothy J.; Sharp, Harriet E. C.; Chui, Miranda T. Y.; Chung, Hugo H. K.; Lau, Stephanie W. S.; Zheng, Jun; Lloyd, Matthew D.; Thompson, Andrew S.; Threadgill, Michael D.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 17 p. 6089 - 6099
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=70 - 80°C; 0.5 h;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 60, # 44 p. 10942 - 10951
反应条件
1: hydrogen bromide / water; dimethyl sulfoxide / 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 20 °C View Scheme
参考文献
WO2011/8572 A2, ;
WO 2011/008572 A2
反应条件
1: With caesium carbonate in DMF (N,N-dimethyl-formamide) 0.5 h; 2: With methyl iodide in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;
参考文献
WO2004/29050 A1, ;
Page 64 ;
WO 2004/029050 A1
反应条件
1: 2-amino-3-methyl benzoic acid With caesium carbonate in N,N-dimethyl-formamide T=20°C; 0.666667 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C;
参考文献
WO2008/65508 A1, ;
Page/Page column 27-28 ;
反应条件
sulfuric acid 72 h; Reflux;
参考文献
Tetrahedron, , vol. 65, # 2 p. 563 - 578
反应条件
in 1,4-dioxane; N-methyl-acetamide; methanol
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 22 p. 3386 - 3396
