2-氨基-3-甲基苯甲酸合成路线 （共 84 条）
反应条件
hydrogenchloride; sodium hydroxide; sodium nitrite; copper(l) chloride in water
参考文献
AstraZeneca AB
Patent: US6255301 B1, 2001 ;
US 6255301 B1
反应条件
hydrogenchloride
18 h; Heating;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
1: methanimidamide monoacetate / 16 h / 160 °C
2: trichlorophosphate / 12 h / 120 °C / |Inert atmosphere
3: toluene-4-sulfonic acid hydrazide / dichloromethane / 12 h / 45 °C / |Inert atmosphere
View Scheme
参考文献
MERCK PATENT GMBH; HUCK, Bayard R.; CHEN, Xiaoling; XIAO, Yufang; LAN, Ruoxi; DE SELM, Lizbeth Celeste; NEAGU, Constantin; POTNICK, Justin; KARRA, Srinivasa, R.; JOHNSON, Theresa, L.
Patent: WO2013/96194 A1, 2013 ;
反应条件
1: 2-amino-3-methyl benzoic acid With hydrogenchloride; sodium hydroxide; sodium nitrite in water
Cooling with ice;
2: potassium ethylxanthate in water
T=80°C;
3: With hydrogenchloride in water
T=20°C;
参考文献
Institute Of Medicinal Molecular Design, Inc.; ShionogiandCo., Ltd.
Patent: EP2208728 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
Yield given. Multistep reaction;
参考文献
Collman, James P.; Groh, Susan E.
Journal of the American Chemical Society, 1982 , vol. 104, # 5 p. 1391 - 1403
反应条件
hydrogenchloride; sodium hydroxide; Na2S*9H2O; hydrogen sulfide; sodium nitrite in water; acetic acid
参考文献
USV Pharmaceutical Corporation
Patent: US4440941 A1, 1984 ;
参考文献
Montoya-Pelaez, Pedro J.; Uh, Yoon-Seo; Lata, Christopher; Thompson, Matthew P.; Lemieux, Robert P.; Crudden, Cathleen M.
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 5921 - 5929
参考文献
Pfizer Inc.
Patent: US4085213 A1, 1978 ;
反应条件
1: T=160°C; 6 h;
2: With water
T=100°C; 0.0833333 h;
参考文献
Smits, Rogier A.; Lim, Herman D.; Van Der Meer, Tiffany; Kuhne, Sebastiaan; Bessembinder, Karin; Zuiderveld, Obbe P.; Wijtmans, Maikel; De Esch, Iwan J.P.; Leurs, Rob
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 461 - 467
反应条件
acetic acid in polyethyleneglycol (PEG-400)
T=20 - 60°C; 0.166667 h;
参考文献
Sharafi-Kolkeshvandi, Mahnaz; Nikpour, Farzad
Chinese Chemical Letters, 2012 , vol. 23, # 4 p. 431 - 433
