2-氨基-3-甲基苯甲酸合成路线 （共 84 条）
参考文献
SmithKline Beecham Intercredit B.V.
Patent: EP322133 B1, 1991 ;
Title/Abstract Full Text Show Details
SmithKline Beecham Intercredit B.V.
Patent: EP322133 A1, 1989 ;
反应条件
T=125°C; 0.0833333 h;
参考文献
Maskey, Rajendra P.; Shaaban, Mohamed; Gruen-Wollny, Iris; Laatsch, Hartmut
Journal of Natural Products, 2004 , vol. 67, # 7 p. 1131 - 1134
反应条件
1: 73 percent / LiAlH4 / diethyl ether / 4 h / Heating
2: 85 percent / manganese(IV) oxide / diethyl ether / 6 h / Heating
View Scheme
参考文献
Mao, Mingzhen; Li, Yuxin; Liu, Qiaoxia; Zhou, Yunyun; Zhang, Xiulan; Xiong, Lixia; Li, Yongqiang; Li, Zhengming
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 42 - 46
反应条件
1: N-iodo-succinimide / N,N-dimethyl-formamide / 1 h / 75 °C / Inert atmosphere
2: N,N-dimethyl-formamide / 20 h / 140 °C / Inert atmosphere
View Scheme
参考文献
Allendoerfer, Nadine; Es-Sayed, Mazen; Nieger, Martin; Braese, Stefan
Tetrahedron Letters, 2012 , vol. 53, # 4 p. 388 - 391
反应条件
1: 98 percent / patassium carbonate,copper(I) bromide, copper / various solvent(s) / 0.5 h / 160 °C
2: 86 percent / conc. H2SO4 / 90 deg C, 2 h; 25 deg C, overnight
3: thionyl chloride / dimethylformamide / 0.67 h / Heating
4: H2O; CHCl3 / 0.5 h / 0 °C
View Scheme
参考文献
Brennan; Colbry; Leeds; Leja; Priebe; Reily; Showalter; Uhlendorf; Atwell; Denny
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1469 - 1476
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 0.67 h / 100 °C
2: thionyl chloride / 3 h / |Reflux
3: tetrahydrofuran / 20 °C / |Cooling with ice
View Scheme
参考文献
Zhao, Yu; Li, Yongqiang; Xiong, Lixia; Wang, Hongxue; Li, Zhengming
Chinese Journal of Chemistry, 2012 , vol. 30, # 8 p. 1748 - 1758
反应条件
1: 98 percent / patassium carbonate,copper(I) bromide, copper / various solvent(s) / 0.5 h / 160 °C
2: 86 percent / conc. H2SO4 / 90 deg C, 2 h; 25 deg C, overnight
3: thionyl chloride / dimethylformamide / 0.67 h / Heating
View Scheme
参考文献
Brennan; Colbry; Leeds; Leja; Priebe; Reily; Showalter; Uhlendorf; Atwell; Denny
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1469 - 1476
反应条件
1: 78 percent / NaNO2, Cu(I)-salt
2: 95 percent / LiAlH4 / diethyl ether
3: 93 percent / PBr3 / toluene
View Scheme
参考文献
Keller, Felix; Rippert, Andreas Johannes
Helvetica Chimica Acta, 1999 , vol. 82, # 1 p. 125 - 137
反应条件
1: 87 percent / 2 h / Heating
2: 99 percent / HNO3; sulfuric acid / 8 h / 0 - 5 °C
View Scheme
参考文献
Montoya-Pelaez, Pedro J.; Uh, Yoon-Seo; Lata, Christopher; Thompson, Matthew P.; Lemieux, Robert P.; Crudden, Cathleen M.
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 5921 - 5929
反应条件
1.1: NaNO2; HCl
1.2: 84 percent / KI / H2O
2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
3.1: 7.19 g / sodium borohydride / methanol / 1.42 h / 0 °C
4.1: 79 percent / PPh3; NBS / CH2Cl2 / 3 h
5.1: NaH / tetrahydrofuran / 25 °C
5.2: 80 percent / tetrahydrofuran / 20 °C
View Scheme
参考文献
Curran, Dennis P.; Fairweather, Neil
Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2972 - 2974
