1-苯基-2-丙烯-1-醇合成路线 （共 252 条）
反应条件
2: 2.) 30percent H2O2, NaHCO3 / 1.) H2PtCl6*6H2O
View Scheme
参考文献
Tamao, Kohei; Tanaka, Tetsu; Nakajima, Takashi; Sumiya, Ritsuo; Arai, Hitoshi; Ito, Yoshihiko
Tetrahedron Letters, 1986 , vol. 27, # 29 p. 3377 - 3380
反应条件
2: 89 percent / Cl2(PCy3)2Ru=CHPh / CH2Cl2 / Heating
3: 77 percent / CrO3; 3,5-dimethylpyrazole / CH2Cl2 / 1 h / -20 °C
View Scheme
参考文献
Marco, J. Alberto; Carda, Miguel; Rodriguez, Santiago; Castillo, Encarnacion; Kneeteman, Maria N.
Tetrahedron, 2003 , vol. 59, # 23 p. 4085 - 4101
参考文献
Moureu; Gallagher
Bulletin de la Societe Chimique de France, 1921 , vol. <4> 29, p. 1010
反应条件
(S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (R)-phenyl vinyl carbinol in ethylene dibromide
T=23 - 50°C; 24 h; Inert atmosphere; enantioselective reaction;
参考文献
Roggen, Markus; Carreira, Erick M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8652 - 8655
反应条件
tris(acetonitrile)(η5-2,4-cyclopentadien-1-yl)ruthenium(1+) hexafluorophosphate(1-); (1S)-10-camphorsulfonic acid in acetonitrile-D3
120 h;
参考文献
Zaitsev, Alexey B.; Caldwell, Helen F.; Pregosin, Paul S.; Veiros, Luis F.
Chemistry - A European Journal, 2009 , vol. 15, # 26 p. 6468 - 6477
反应条件
tris(acetonitrile)(η5-2,4-cyclopentadien-1-yl)ruthenium(1+) hexafluorophosphate(1-); (1S)-10-camphorsulfonic acid in acetonitrile-D3
0.5 h;
参考文献
Zaitsev, Alexey B.; Caldwell, Helen F.; Pregosin, Paul S.; Veiros, Luis F.
Chemistry - A European Journal, 2009 , vol. 15, # 26 p. 6468 - 6477
反应条件
1: (S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium / 1,2-dichloro-ethane / 24 h / 23 - 50 °C / Inert atmosphere
2: (S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; (S)-phenyl vinyl carbinol / 1,2-dichloro-ethane / 24 h / 23 - 50 °C / Inert atmosphere
3: (S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; C11H11ClO2 / 1,2-dichloro-ethane / 24 h / 23 - 50 °C / Inert atmosphere
View Scheme
参考文献
Roggen, Markus; Carreira, Erick M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8652 - 8655
反应条件
(S)-(+)-N-(3,5-dioxa-4-phosphacyclohepta-[2,1-a;3,4-a′]dinaphthalen-4-yl)dibenz[b,f]azepine; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; zinc(II) chloride in 1,2-dichloro-ethane
Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Roggen, Markus; Carreira, Erick M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8652 - 8655
反应条件
tris(acetonitrile)(η5-2,4-cyclopentadien-1-yl)ruthenium(1+) hexafluorophosphate(1-); (1S)-10-camphorsulfonic acid in acetonitrile-D3
1.33333 h;
参考文献
Zaitsev, Alexey B.; Caldwell, Helen F.; Pregosin, Paul S.; Veiros, Luis F.
Chemistry - A European Journal, 2009 , vol. 15, # 26 p. 6468 - 6477
反应条件
n-butyllithium; triphenylborane; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine
1.) THF, r.t., 5 min; 2.) r.t., 10 min; 3.) THF, reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Stary, Ivo; Stara, Irena G.; Kocovsky, Pavel
Tetrahedron, 1994 , vol. 50, # 2 p. 529 - 538
