tert.-butyl lithium 1.) THF, from -70 deg C to 65 deg C, 45 min, 2.) THF, from -65 deg C to RT, 12 h; Yield givenMultistep reaction;
参考文献
Bonhote, Pierre; Moser, Jacques-E.; Humphry-Baker, Robin; Vlachopoulos, Nicolas; Zakeeruddin, Shaik M.; Walder, Lorenz; Graetzel, Michael
Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1324 - 1336
1: 5-Bromo-2,4-dichloror-pyrimidine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=78°C; 1 h; 2: (4-morpholinyl)methanone in tetrahydrofuran T=-78 - -35°C; 1.5 h; 3: With hydrogenchloride; water in tetrahydrofuran T=-35°C;
参考文献
ABBOTT LABORATORIES; WOLLER, Kevin R.; CURTIN, Michael L.; FRANK, Kristine E.; JOSEPHSOHN, Nathan S.; LI, Biqin C.; WISHART, Neil
Patent: WO2011/156698 A2, 2011 ;
Location in patent: Page/Page column 52 ;
WO 2011/156698 A2