4-(羟基甲基)-2,6-二甲基苯酚合成路线 （共 42 条）
反应条件
sodium tetrahydroborate in methanol T=15 - 20°C; 1 h;
参考文献
ENZON PHARMACEUTICALS, INC.
Patent: WO2004/43884 A2, 2004 ;
Location in patent: Page 25 ;
反应条件
in water T=30°C; 2.5 h;
参考文献
Barbier, Michael; Barton, Derek H. R.; Devys, Michel; Topgi, Ravindra Satish
Tetrahedron, 1987 , vol. 43, # 21 p. 5031 - 5038
反应条件
sodium hydroxide; formaldehyd; acetic acid in water
参考文献
Warner-Lambert Co.
Patent: US5166398 A1, 1992 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Naganawa, Atsushi; Matsui, Toshiaki; Ima, Masaki; Yoshida, Koji; Tsuruta, Hiroshi; Yamamoto, Shingo; Yamamoto, Hiroshi; Okada, Hiroki; Maruyama, Takayuki; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7774 - 7789
反应条件
peroxymonosulfuric acid
参考文献
Magnusson,R.
Acta Chemica Scandinavica (1947-1973), 1964 , vol. 18, p. 759 - 768
反应条件
1: tetrahydrofuran; diethyl ether / 0 °C 2: 1.78 g / lithium aluminum hydride / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Naganawa, Atsushi; Matsui, Toshiaki; Ima, Masaki; Yoshida, Koji; Tsuruta, Hiroshi; Yamamoto, Shingo; Yamamoto, Hiroshi; Okada, Hiroki; Maruyama, Takayuki; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7774 - 7789
反应条件
sodium hydroxide 18 h; Ambient temperature; Yields of byproduct given;
参考文献
Massy, D. J. R.; McKillop, A.
Synthesis, 1989 , # 4 p. 253 - 255
反应条件
oxygen; horseradish peroxidase Oxidation; pH=7; electrolysis after 2 F;
参考文献
Pletcher, Derek
Acta Chemica Scandinavica, 1999 , vol. 53, # 10 p. 745 - 750
反应条件
sodium hydroxide; phosphoric acid in acetonitrile T=25°C; pH=4.0; Kinetics; Further Variations:pH-values;
参考文献
Zhou; Turnbull
Journal of Organic Chemistry, 2001 , vol. 66, # 21 p. 7072 - 7077
反应条件
water in acetonitrile T=25°C; pH=4.0; Kinetics; Further Variations:pH-valuesTemperaturesSolvents;
参考文献
Zhou; Turnbull
Journal of Organic Chemistry, 2001 , vol. 66, # 21 p. 7072 - 7077
