(S)-1-[(4-氯苯基)苯甲基]哌嗪合成路线 （共 10 条）
反应条件
sodium hydroxide in n-heptane; water T=55°C; pH=13 - 14; 2 h;
参考文献
CIPLA LIMITED; CURTIS, Philip, Anthony
Patent: WO2009/147389 A2, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
in ethyl acetate T=20 - 60°C; 12 h; Purification / work up;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2009/78627 A2, 2009 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With 1-chloroethyl chlorocarbonate in tetrahydrofuran; methanol 3 h; Reflux; 2: With methanol in tetrahydrofuran 16 h; Reflux; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2011/184174 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
1.1: 90 percent / Ti(OEt)4 / tetrahydrofuran / 22 °C 2.1: diethyl ether / -20 °C 2.2: HCl / methanol / 22 °C 3.1: iPr2NEt 4.1: HBr; acetic acid; 4-OH-PhCOOH View Scheme
参考文献
Pflum, Derek A; Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A; Senanayake, Chris H
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 923 - 926
反应条件
1.1: diethyl ether / -20 °C 1.2: HCl / methanol / 22 °C 2.1: iPr2NEt 3.1: HBr; acetic acid; 4-OH-PhCOOH View Scheme
参考文献
Pflum, Derek A; Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A; Senanayake, Chris H
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 923 - 926
反应条件
1: 85 percent / Ti(OEt)4 / tetrahydrofuran / 22 °C 2: toluene / -20 - 0 °C 3: 95 percent / HCl / methanol / 22 °C 4: iPr2NEt 5: HBr; acetic acid; 4-OH-PhCOOH View Scheme
参考文献
Pflum, Derek A; Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A; Senanayake, Chris H
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 923 - 926
反应条件
1: toluene / -20 - 0 °C 2: 95 percent / HCl / methanol / 22 °C 3: iPr2NEt 4: HBr; acetic acid; 4-OH-PhCOOH View Scheme
参考文献
Pflum, Derek A; Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A; Senanayake, Chris H
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 923 - 926
反应条件
1: 95 percent / HCl / methanol / 22 °C 2: iPr2NEt 3: HBr; acetic acid; 4-OH-PhCOOH View Scheme
参考文献
Pflum, Derek A; Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A; Senanayake, Chris H
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 923 - 926
反应条件
hydrogen bromide; acetic acid; 4-hydroxy-benzoic acid
参考文献
Pflum, Derek A; Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A; Senanayake, Chris H
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 923 - 926
反应条件
1: iPr2NEt 2: HBr; acetic acid; 4-OH-PhCOOH View Scheme
参考文献
Pflum, Derek A; Krishnamurthy, Dhileepkumar; Han, Zhengxu; Wald, Stephen A; Senanayake, Chris H
Tetrahedron Letters, 2002 , vol. 43, # 6 p. 923 - 926
