2-氯-N-异丙基吡啶-4-甲酰胺合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane
T=0°C; 2 h;
参考文献
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.)
Patent: WO2006/33011 A1, 2006 ;
Location in patent: Page/Page column 36 ;
反应条件
1: 2-chloro-pyridine-4-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide in acetonitrile
1 h; Heating;
2: isopropylamine With triethylamine in dichloromethane
T=0°C; 2 h;
参考文献
Peters, Rene; Althaus, Martin; Diolez, Christian; Rolland, Alain; Manginot, Eric; Veyrat, Marc
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7583 - 7595
反应条件
1: thionyl chloride / 1 h / Heating
2: triethylamine / benzene / 1 h / Heating
View Scheme
参考文献
Pavlova; Mikhalev; Kon'shin; Vasilyuk; Kotegov
Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 8 p. 425 - 427
