4-溴-3-(4-硝基苯基)-吡啶合成路线 （共 2 条）
反应条件
1: 4-bromo-pyridine-hydrochloride With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: 1-bromo-4-nitro-benzene With zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
3 h; Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; AUSTIN, Joel, Francis; SHARMA, Lisa, S.; BALOG, James, Aaron; HUANG, Audris; VELAPARTHI, Upender; DARNE, Chetan, Padmakar; SAULNIER, Mark, George
Patent: WO2012/15723 A1, 2012 ;
Location in patent: Page/Page column 78 ;
WO 2012/015723 A1
反应条件
1: 4-bromo-pyridine-hydrochloride With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: With zinc(II) chloride in tetrahydrofuran
T=-78 - 20°C;
3: para-nitro iodo-benzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
Negishi coupling; 3 h; Heating;
参考文献
Karig, Gunter; Thasana, Nopporn; Gallagher, Timothy
Synlett, 2002 , # 5 p. 808 - 810
