3-苯基丙-2-烯-1-醇合成路线 （共 318 条）
反应条件
1: MCPBA / CH2Cl2 / 0 deg C, 1.5 h, then RT, 24 h 2: 1.) NaOH / 1.) H2O, 70 deg C; 2.) H2O, 70 deg C, 2.5 h 3: 61 percent / pyridine / 2 h / -10 °C 4: 84 percent / Et3N / CH2Cl2 / 0.5 h / 0 - 5 °C 5: 2N NaOH / dioxane / 4 h / Ambient temperature 6: 32percent NH4OH / methanol / 6 h / sealed flask 7: 98 percent / Et3N / CH2Cl2 / 0.5 h / -10 - -5 °C 8: 86 percent / t-BuOK / 2-methyl-propan-2-ol / 3 h / Ambient temperature 9: RED-AL / toluene / 4 h / Ambient temperature View Scheme
参考文献
Melloni; Della Torre; Lazzari; et al.
Tetrahedron, 1985 , vol. 41, # 7 p. 1393 - 1399
反应条件
dihydrogen peroxide; (+)-Weinsaeure-diethylester; titanium-pillared montmorillonite catalyst (Ti-PILC) in dichloromethane T=-20 - -15°C; 3.5 h;
参考文献
Sasikumar; Nikalje, Milind D.
Synthetic Communications, 2012 , vol. 42, # 20 p. 3061 - 3067
反应条件
titanium(IV) isopropylate; tert.-butylhydroperoxide; (-)-(1S,3S)-1,2-bis(2-methoxyphenyl)ethane-1,2-diol in dichloromethane T=-20°C; 18 h;
参考文献
Yamamoto, Koji; Ando, Hiroyuki; Shuetake, Takashi; Chikamatsu, Hiroaki
Journal of the Chemical Society, Chemical Communications, 1989 , # 12 p. 754 - 756
反应条件
lt;N-(1,8-naphthalenedicarbonyl)-tert-Leu-lt;N-bis(1-naphthyl); vanadium triisopropoxide oxide in toluene T=0°C; 80 h; Title compound not separated from byproducts.;
参考文献
Hoshino; Yamamoto
Journal of the American Chemical Society, 2000 , vol. 122, # 42 p. 10452 - 10453
反应条件
in toluene T=90°C; 3 h;
参考文献
McFarland, John W.; Schut, Dirk; Zwanenburg, Binne
Tetrahedron, 1981 , vol. 37, p. 389 - 393
反应条件
1,4-dioxane; copper (II) chromite T=270 - 280°C; P=147102 Torr; Hydrogenation;
参考文献
Waser
Helvetica Chimica Acta, 1925 , vol. 8, p. 124
反应条件
T=270 - 280°C; P=154457 Torr; Hydrogenation;
参考文献
Bower; Cooke; Hibbert
Journal of the American Chemical Society, 1943 , vol. 65, p. 1192,1195
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride in tetrahydrofuran T=20°C; Inert atmosphere; optical yield given as percent destereoselective reaction;
参考文献
Wang, Xiang-Bo; Zou, Xiao-Lei; Du, Guang-Fen; Liu, Zhi-Yong; Dai, Bin
Tetrahedron, 2012 , vol. 68, # 32 p. 6498 - 6503
反应条件
potassium carbonate; butanone; amino alcohol-based Ir bifunctional catalyst T=20°C; 17 h;
参考文献
Suzuki, Takeyuki; Matsuo, Tomohito; Watanabe, Kazuhiro; Katoh, Tadashi
Synlett, 2005 , # 9 art. no. U05305ST, p. 1453 - 1455
反应条件
1,3-dibenzyl-1H-benzo[d]imidazol-3-ium chloride; caesium carbonate in 1,4-dioxane T=20°C; 3 h; Inert atmosphere; stereoselective reaction;
参考文献
Zhang, Bo; Feng, Peng; Cui, Yuxin; Jiao, Ning
Chemical Communications, 2012 , vol. 48, # 58 p. 7280 - 7282
