3-苯基丙-2-烯-1-醇合成路线 （共 318 条）
反应条件
sodium; copper
T=280°C;
参考文献
Weizmann; Bergmann; Haskelberg
Chemistry and Industry (London, United Kingdom), 1937 , p. 587,590
反应条件
1: (trans)-β-nitrostyrene With n-butyllithium in ethylene glycol dimethyl ether; hexane
T=-78°C;
2: 3-phenyl-2-propen-1-ol (cinnamyl alcohol) in ethylene glycol dimethyl ether; hexane
T=-78°C; oxa-Michael addition;
参考文献
Jahn, Ullrich; Rudakov, Dmytro
Synlett, 2004 , # 7 p. 1207 - 1210
反应条件
1: 3-phenyl-2-propen-1-ol (cinnamyl alcohol) With n-butyllithium in ethylene glycol dimethyl ether; hexane
T=-78°C; 0.25 h;
2: (trans)-β-nitrostyrene in ethylene glycol dimethyl ether; hexane
T=-50 - -40°C; oxa-Michael addition;
3: With copper dichloride in ethylene glycol dimethyl ether; hexane
T=0°C; 0.5 h;
参考文献
Jahn, Ullrich; Rudakov, Dmytro
Synlett, 2004 , # 7 p. 1207 - 1210
反应条件
1: 1) Propionsaeure, 2a) conc. HCl, 2b) H2O/methanol/KOH / 1) 140-150 deg C, 2a) 110 deg C, 2b) reflux, 2h
2: 1) NaHCO3, KI, I2, 2) DBU / 1) H2O, 12 h, 2) benzene, 70 80 deg C, 3 h
View Scheme
参考文献
Guenther, Hans Juergen; Guntrum, Eberhard; Jaeger, Volker
Liebigs Annalen der Chemie, 1984 , # 1 p. 15 - 30
反应条件
1: aluminium tert-butylate; benzene / 90 - 95 °C
View Scheme
参考文献
Batty et al.
Journal of the Chemical Society, 1938 , p. 175,178
反应条件
VO(OTf)2 in dichloromethane
T=20°C; 72 h;
参考文献
Chen, Chien-Tien; Chang, I-Hsin; Lin, Jin-Sheng; Liu, Chin-Jing; Chou, Y-Chen; Kuo, Jen-Huang; Li, Chun-Hsin; Barhate; Hon, Sang-Wen; Li, Tai-Wei; Chao, Shi-Deh; Liu, Chia-Cheng; Li, Ying-Chieh
Organic Letters, 2001 , vol. 3, # 23 p. 3729 - 3732
反应条件
phosphoric acid in benzene
T=75 - 80°C; 12 h;
参考文献
Ahluwalia, V. K.; Arora, K. K.; Mukherjee, Keya
Synthesis, 1984 , # 4 p. 346 - 348
反应条件
in toluene
T=70°C; 19 h;
参考文献
Hartmann, Benoit; Kanazawa, Alice M.; Depres, Jean-Pierre; Greene, Andrew E.
Tetrahedron Letters, 1991 , vol. 32, # 38 p. 5077 - 5080
反应条件
copper; Cu(II) perchlorate; ethyl acetate in benzene
8 h; Heating; Yield given;
参考文献
Baruah, Jubaraj B.; Samuelson, Ashoka G.
Journal of Organometallic Chemistry, 1989 , vol. 361, p. C57 - C60
反应条件
1.1: pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C
2.1: manganese; trifluoroacetic acid; cobalt(II) dibromide / acetonitrile / 0.08 h / 20 °C
2.2: 80 °C
View Scheme
参考文献
Qian, Xin; Auffrant, Audrey; Felouat, Abdellah; Gosmini, Corinne
Angewandte Chemie - International Edition, 2011 , vol. 50, # 44 p. 10402 - 10405
