3-苯基丙-2-烯-1-醇合成路线 （共 318 条）
反应条件
1: PBr3, pyridine / petroleum ether; diethyl ether / 1 h / -15 °C
2: 1.) 1 N KOH, 2.) KI / 2.) HMPT, 45 deg C, 16 h
3: 93 percent / conc. H2SO4 / 0.25 h / 20 °C
View Scheme
参考文献
Schaffner-Sabba, Karl; Schmidt-Ruppin, Karl H.; Wehrli, Walter; Schuerch, ALfred R.; Wasley, Jan W. F.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 990 - 994
反应条件
1: With manganese(IV) oxide; sodium tetrahydroborate in dichloromethane
17 h; Heating;
2: With methanol
T=0 - 20°C; 0.666667 h;
参考文献
Kanno, Hisashi; Taylor, Richard J.K.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7337 - 7340
反应条件
Pt(COD)Cl2; bis[2-(diphenylphosphino)phenyl] ether in 1,4-dioxane
18 h; Heating;
参考文献
Utsunomiya, Masaru; Miyamoto, Yoshiki; Lpposhi, Junji; Ohshima, Takashi; Mashima, Kazushi
Organic Letters, 2007 , vol. 9, # 17 p. 3371 - 3374
反应条件
1: mercury(II) acetate / 30 h / Heating
2: 41 percent / chloro(5,10,15,20-tetraphenylporphyrinato)chromium(III) / 1,2-dichloro-ethane / 52 h / 83 °C
View Scheme
参考文献
Buechi, George; Vogel, Dennis E.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5406 - 5408
反应条件
mercury(II) diacetate; sodium acetate
T=180°C; Claisen rearrangement; 4 h;
参考文献
Tokuyama, Hidetoshi; Makido, Takaki; Ueda, Toshihiro; Fukuyama, Tohru
Synthetic Communications, 2002 , vol. 32, # 6 p. 869 - 873
反应条件
1: MCPBA / CH2Cl2 / 0 deg C, 1.5 h, then RT, 24 h
2: 1.) NaOH / 1.) H2O, 70 deg C; 2.) H2O, 70 deg C, 2.5 h
3: 61 percent / pyridine / 2 h / -10 °C
4: 84 percent / Et3N / CH2Cl2 / 0.5 h / 0 - 5 °C
5: 2N NaOH / dioxane / 4 h / Ambient temperature
6: 32percent NH4OH / methanol / 6 h / sealed flask
7: ethyl acetate / 16 h
View Scheme
参考文献
Assaf, Georges; Checksfield, Graham; Critcher, Doug; Dunn, Peter J.; Field, Stuart; Harris, Laurence J.; Howard, Roger M.; Scotney, Gemma; Scott, Adam; Mathew, Suju; Walker, Geoffrey M. H.; Wilder, Alexander
Green Chemistry, 2012 , vol. 14, # 1 p. 123 - 129
反应条件
dirhodium(II) tetrakis(perfluorobutyrate) in dichloromethane
15 h; Ambient temperature;
参考文献
Doyle, Michael P.; High, Kenneth G.; Bagheri, Vahid; Pieters, Roland J.; Lewis, Patricia J.; Pearson, Matthew M.
Journal of Organic Chemistry, 1990 , vol. 55, # 25 p. 6082 - 6086
反应条件
tetrabutylammomium bromide; sodium formate; sodium hydrogencarbonate; Pd-benzothiazole carbene
T=130°C; Heck reaction; 6 h;
参考文献
Calo, Vincenzo; Nacci, Angelo; Monopoli, Antonio; Spinelli, Michele
European Journal of Organic Chemistry, 2003 , # 8 p. 1382 - 1385
反应条件
tetrabutylammomium bromide; sodium hydrogencarbonate; palladium diacetate
T=130°C; Heck arylation; 6 h;
参考文献
Calo, Vincenzo; Nacci, Angelo; Monopoli, Antonio; Ferola, Valentina
Journal of Organic Chemistry, 2007 , vol. 72, # 7 p. 2596 - 2601
反应条件
tetrabutylammomium bromide; sodium hydrogencarbonate; palladium diacetate
T=110°C; Heck arylation; 5 h;
参考文献
Calo, Vincenzo; Nacci, Angelo; Monopoli, Antonio; Ferola, Valentina
Journal of Organic Chemistry, 2007 , vol. 72, # 7 p. 2596 - 2601
