2,4,6-三甲基苯乙酸合成路线 （共 32 条）
反应条件
1: carbon monoxide With C28H22CoN4O6 in butan-1-ol T=60°C; P=760.051 Torr; 2 h; GloveboxHigh pressureGreen chemistry; 2: 2,4,6-trimethylphenylmethylchloride With tetra-(n-butyl)ammonium iodide; sodium hydroxide in butan-1-ol T=60°C; P=760.051 Torr; 22 h; GloveboxHigh pressureGreen chemistry; regioselective reaction;
参考文献
She, Meng-Yao; Xiao, Da-Wei; Yin, Bing; Yang, Zheng; Liu, Ping; Li, Jian-Li; Shi, Zhen
Tetrahedron, 2013 , vol. 69, # 35 p. 7264 - 7268
反应条件
sulfuric acid Erhitzen auf Siedetemperatur;
参考文献
Lutz; Hinkley
Journal of the American Chemical Society, 1950 , vol. 72, p. 4091
反应条件
hydrogenchloride; sodium hydroxide; sulfuric acid; aluminium trichloride in water; 1,3,5-trimethyl-benzene
参考文献
Bayer Aktiengesellschaft
Patent: US5698735 A1, 1997 ;
反应条件
pentacarbonyliron(0); tetra-n-butyl-ammonium sulfate in sodium hydroxide; toluene T=60°C; P=45600 Torr; 26 h;
参考文献
Tanguy, Guy; Weinberger, Berndt; Abbayes, Herve des
Tetrahedron Letters, 1983 , vol. 24, # 37 p. 4005 - 4008
反应条件
indium; ND4Cl, deuterated ammonium chloride in THF-d8 (tetrahydrofuran-d8); water-d2 T=20°C; 40 h; Reflux; chemoselective reaction;
参考文献
Mineno, Tomoko; Hirayama, Haruyasu; Nakahara, Kazuhide; Yamashita, Mitsuaki; Kansui, Hisao; Moriwaki, Hiroshi
Tetrahedron Letters, 2010 , vol. 51, # 46 p. 6045 - 6048
反应条件
[NiCl2(1,2-dimethoxyethane)]; C15H27P*(x)BF4*H(1+); magnesium chloride; zinc in N,N-dimethyl-formamide T=20°C; P=760.051 Torr; Schlenk technique;
参考文献
Leon, Thierry; Correa, Arkaitz; Martin, Ruben
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1221 - 1224
反应条件
1: aq. NaOH View Scheme
参考文献
Rand,L.; Mohar,A.F.
Journal of Organic Chemistry, 1965 , vol. 30, p. 3885 - 3888
反应条件
hydrogenchloride; amalgamated zinc
参考文献
Lock
Oest. Chemiker-Ztg., 1950 , vol. 51, p. 77
反应条件
methyloxirane in water; acetonitrile 6 h; Irradiation;
参考文献
Dhavale, Dilip D.; Mali, Vasant P.; Sudrik, Surendra G.; Sonawane, Harikisan R.
Tetrahedron, 1997 , vol. 53, # 49 p. 16789 - 16794
反应条件
phosphorus; iodine; acetic acid
参考文献
Weinstock; Fuson
Journal of the American Chemical Society, 1936 , vol. 58, p. 1233,1235
