2-(4-溴苄基)-1,3-二氧戊环合成路线 （共 3 条）
反应条件
p-toluenesulfonic acid monohydrate in ethylene glycol; toluene
参考文献
Merck Frosst Canada, Inc.
Patent: US5710170 A1, 1998 ;
US 5710170 A
反应条件
1: 2-(4-bromophenyl)ethylalchol With Dess-Martin periodane in dichloromethane
T=0 - 20°C; 2 h;
2: ethylene glycol With toluene-4-sulfonic acid in toluene
2 h; Reflux;
参考文献
CHIESI FARMACEUTICI S.p.A.; RANCATI, Fabio; RIZZI, Andrea; AMARI, Gabriele; BIAGETTI, Matteo; LINNEY, Ian
Patent: WO2012/168359 A1, 2012 ;
Location in patent: Page/Page column 104; 105 ;
WO 2012/168359 A1
反应条件
iodine in 1,4-dioxane
T=20°C; 5 h;
参考文献
Kumar, Macharla Arun; Swamy, Peraka; Naresh, Mameda; Reddy, Marri Mahender; Rohitha, Chozhiyath Nappunni; Prabhakar, Sripadi; Sarma, Akella Venkata Subrahmanya; Kumar, Joseph Richard Prem; Narender, Nama
Chemical Communications, 2013 , vol. 49, # 17 p. 1711 - 1713
